Van Voorhis, Wesley C; Hulverson, Matthew A; Choi, Ryan; Huang, Wenlin; Arnold, Samuel L M; Schaefer, Deborah A; Betzer, Dana P; Vidadala, Rama S R; Lee, Sangun; Whitman, Grant R; Barrett, Lynn K; Maly, Dustin J; Riggs, Michael W; Fan, Erkang; Kennedy, Thomas J; Tzipori, Saul; Doggett, J Stone; Winzer, Pablo; Anghel, Nicoleta; Imhof, Dennis; ... (2021). One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases. Veterinary parasitology, 289, p. 109336. Elsevier 10.1016/j.vetpar.2020.109336
![[img]](https://boris.unibe.ch/style/images/fileicons/text.png) |
Text
1-s2.0-S0304401720303162-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (2MB) |
This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of One Health parasitic apicomplexan diseases. Many apicomplexan infections are shared between humans and livestock, such as cryptosporidiosis and toxoplasmosis, as well as livestock only diseases such as neosporosis. We have demonstrated proof-of-concept for BKI therapy in livestock models of cryptosporidiosis (newborn calves infected with Cryptosporidium parvum), toxoplasmosis (pregnant sheep infected with Toxoplasma gondii), and neosporosis (pregnant sheep infected with Neospora caninum). We discuss the potential uses of BKIs for the treatment of diseases caused by apicomplexan parasites in animals and humans, and the improvements that need to be made to further develop BKIs.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Winzer, Pablo Arnold, Anghel, Nicoleta, Imhof, Dennis, Müller, Heinz Joachim, Hemphill, Andrew |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
1873-2550 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Andrew Hemphill |
Date Deposited: |
17 Feb 2021 14:33 |
Last Modified: |
02 Mar 2023 23:34 |
Publisher DOI: |
10.1016/j.vetpar.2020.109336 |
PubMed ID: |
33418437 |
Uncontrolled Keywords: |
Antiparastics Apicomplexa Kinase inhibitors |
BORIS DOI: |
10.48350/152361 |
URI: |
https://boris.unibe.ch/id/eprint/152361 |
Actions (login required)
 |
Edit item |