Haddad, Tariq Sami; Lugli, Alessandro; Aherne, Susan; Barresi, Valeria; Terris, Benoît; Bokhorst, John-Melle; Brockmoeller, Scarlet Fiona; Cuatrecasas, Miriam; Simmer, Femke; El-Zimaity, Hala; Fléjou, Jean-François; Gibbons, David; Cathomas, Gieri; Kirsch, Richard; Kuhlmann, Tine Plato; Langner, Cord; Loughrey, Maurice B; Riddell, Robert; Ristimäki, Ari; Kakar, Sanjay; ... (2021). Improving tumor budding reporting in colorectal cancer: a Delphi consensus study. Virchows Archiv, 479(3), pp. 459-469. Springer 10.1007/s00428-021-03059-9
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Tumor budding is a long-established independent adverse prognostic marker in colorectal cancer, yet methods for its assessment have varied widely. In an effort to standardize its reporting, a group of experts met in Bern, Switzerland, in 2016 to reach consensus on a single, international, evidence-based method for tumor budding assessment and reporting (International Tumor Budding Consensus Conference [ITBCC]). Tumor budding assessment using the ITBCC criteria has been validated in large cohorts of cancer patients and incorporated into several international colorectal cancer pathology and clinical guidelines. With the wider reporting of tumor budding, new issues have emerged that require further clarification. To better inform researchers and health-care professionals on these issues, an international group of experts in gastrointestinal pathology participated in a modified Delphi process to generate consensus and highlight areas requiring further research. This effort serves to re-affirm the importance of tumor budding in colorectal cancer and support its continued use in routine clinical practice.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology > Translational Research Unit 04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Lugli, Alessandro, Zlobec, Inti |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0945-6317 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Inti Zlobec |
Date Deposited: |
11 Mar 2021 09:47 |
Last Modified: |
05 Dec 2022 15:49 |
Publisher DOI: |
10.1007/s00428-021-03059-9 |
PubMed ID: |
33650042 |
Uncontrolled Keywords: |
Colorectal cancer Delphi study ITBCC Tumor budding |
BORIS DOI: |
10.48350/153600 |
URI: |
https://boris.unibe.ch/id/eprint/153600 |
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