Coronavirus biology and replication: implications for SARS-CoV-2.

V'kovski, Philip; Kratzel, Annika; Steiner, Silvio; Stalder, Hanspeter; Thiel, Volker (2021). Coronavirus biology and replication: implications for SARS-CoV-2. Nature reviews. Microbiology, 19(3), pp. 155-170. Springer Nature 10.1038/s41579-020-00468-6

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The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the human population. Although the previous coronavirus SARS-CoV and MERS-CoV epidemics raised awareness of the need for clinically available therapeutic or preventive interventions, to date, no treatments with proven efficacy are available. The development of effective intervention strategies relies on the knowledge of molecular and cellular mechanisms of coronavirus infections, which highlights the significance of studying virus-host interactions at the molecular level to identify targets for antiviral intervention and to elucidate critical viral and host determinants that are decisive for the development of severe disease. In this Review, we summarize the first discoveries that shape our current understanding of SARS-CoV-2 infection throughout the intracellular viral life cycle and relate that to our knowledge of coronavirus biology. The elucidation of similarities and differences between SARS-CoV-2 and other coronaviruses will support future preparedness and strategies to combat coronavirus infections.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

V'kovski, Philip; Kratzel, Annika; Steiner, Silvio; Stalder, Hanspeter and Thiel, Volker Earl

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1740-1534

Publisher:

Springer Nature

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

13 Jul 2021 10:49

Last Modified:

13 Jul 2021 10:49

Publisher DOI:

10.1038/s41579-020-00468-6

PubMed ID:

33116300

BORIS DOI:

10.48350/156600

URI:

https://boris.unibe.ch/id/eprint/156600

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