The Enigma of Eosinophil Degranulation

Fettrelet, Timothée; Gigon, Lea; Karaulov, Alexander; Yousefi, Shida; Simon, Hans-Uwe (2021). The Enigma of Eosinophil Degranulation. International journal of molecular sciences, 22(13) MDPI 10.3390/ijms22137091

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Eosinophils are specialized white blood cells, which are involved in the pathology of diverse allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as cytotoxic effector cells but have been suggested to additionally play a role in immunomodulation and maintenance of homeostasis. The exact role of these granule-containing leukocytes in health and diseases is still a matter of debate. Degranulation is one of the key effector functions of eosinophils in response to diverse stimuli. The different degranulation patterns occurring in eosinophils (piecemeal degranulation, exocytosis and cytolysis) have been extensively studied in the last few years. However, the exact mechanism of the diverse degranulation types remains unknown and is still under investigation. In this review, we focus on recent findings and highlight the diversity of stimulation and methods used to evaluate eosinophil degranulation.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Fettrelet, Timothée; Gigon, Lea; Yousefi, Shida and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1422-0067

Publisher:

MDPI

Language:

English

Submitter:

Celine Joray

Date Deposited:

06 Jul 2021 11:53

Last Modified:

06 Sep 2021 16:47

Publisher DOI:

10.3390/ijms22137091

PubMed ID:

34209362

Uncontrolled Keywords:

cytolysis degranulation eosinophil extracellular trap eosinophils exocytosis granule proteins piecemeal degranulation

BORIS DOI:

10.48350/157392

URI:

https://boris.unibe.ch/id/eprint/157392

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