Temporal and regional incidence of carbapenemase-producing Enterobacterales, Switzerland, 2013 to 2018.

Ramette, Alban; Gasser, Michael; Nordmann, Patrice; Zbinden, Reinhard; Schrenzel, Jacques; Perisa, Damir; Kronenberg, Andreas (2021). Temporal and regional incidence of carbapenemase-producing Enterobacterales, Switzerland, 2013 to 2018. Eurosurveillance, 26(15) European Centre for Disease Prevention and Control 10.2807/1560-7917.ES.2021.26.15.1900760

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Introduction: In contrast to countries where carbapenemase-producing Enterobacterales (CPE) are endemic, only sporadic cases were reported in Switzerland until 2013. An aggravation of the epidemiological situation in neighbouring European countries indicated the need for a surveillance study in Switzerland.AimWe aimed to describe CPE distributions in Switzerland and identify epidemiological factors associated with changes in incidence.
Methods: Data on all human CPE isolates from 2013 to 2018 were collected by the Swiss Centre for Antibiotic Resistance (ANRESIS) and analysed for temporal and regional trends by Generalised Poisson regression. Isolates associated with infection or colonisation were included in a primary analysis; a secondary analysis included invasive isolates only. Statistical detection of regional clusters was performed with WHONET/SaTScan.
Results: We analysed 731 CPE isolates, of which 325 (44.5%) were associated with screenings and 173 (23.7%) with infections. Yearly detection of CPE isolates increased considerably during the study period from 65 to 212. The most frequently isolated species were Klebsiella pneumoniae (54%) and Escherichia coli (28%). The most frequent genotypes were OXA-48 (43%), KPC (21%) and NDM (14%). In contrast to the French-speaking parts of Switzerland (West, Geneva) where OXA-48 were the predominant genotypes (around 60%), KPC was the most frequently detected genotype in the Italian-speaking region (63%). WHONET/SaTScan outbreak detection analysis identified seven clusters in five regions of Switzerland.
Conclusions:In a first continuous surveillance of CPE in Switzerland, we found that the epidemiological situation aggravated nationwide and that regional patterns of CPE genotypes mirrored the situation in neighbouring European countries.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Ramette, Alban Nicolas; Gasser, Michael and Kronenberg, Andreas Oskar

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1560-7917

Publisher:

European Centre for Disease Prevention and Control

Language:

English

Submitter:

Andreas Oskar Kronenberg

Date Deposited:

23 Jul 2021 08:08

Last Modified:

23 Jul 2021 08:17

Publisher DOI:

10.2807/1560-7917.ES.2021.26.15.1900760

PubMed ID:

33860749

Uncontrolled Keywords:

CPE Carbapenemase-producing Enterobacterales Switzerland genotypes outbreak temporal and regional trends

BORIS DOI:

10.48350/157698

URI:

https://boris.unibe.ch/id/eprint/157698

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