Functional expression of CD134 by neutrophils.

Baumann, Ralf; Yousefi, Shida; Simon, Dagmar; Russmann, Stefan; Mueller, Christoph; Simon, Hans-Uwe (2004). Functional expression of CD134 by neutrophils. European journal of immunology, 34(8), pp. 2268-2275. Wiley-VCH 10.1002/eji.200424863

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CD134 (OX40) is a member of the tumor necrosis factor (TNF) receptor superfamily expressed on activated T cells. Here, we show that human peripheral blood neutrophils express CD134. Activation of CD134 by soluble CD134 ligand (OX40 ligand/gp34) resulted in delayed caspase-3 activation and consequently in delayed neutrophil apoptosis in vitro. Moreover, CD134 ligand, like G-CSF, maintained anti-apoptotic Mcl-1 levels and inhibited cleavage of the pro-apoptotic Bcl-2 family members Bid and Bax in these cells, suggesting that CD134-mediated signals block apoptosis pathways proximal to mitochondria activation. In conclusion, CD134 regulates neutrophil survival, suggesting that this molecule does not only contribute to adaptive but also to innate immune responses.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Yousefi, Shida, Simon, Dagmar, Müller, Christoph (C), Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0014-2980

Publisher:

Wiley-VCH

Language:

English

Submitter:

Christoph Müller

Date Deposited:

27 Sep 2022 07:03

Last Modified:

29 Mar 2023 23:38

Publisher DOI:

10.1002/eji.200424863

PubMed ID:

15259024

BORIS DOI:

10.48350/173176

URI:

https://boris.unibe.ch/id/eprint/173176

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