Programmed Death-Ligand 1 Expression in Lung Cancer and Paired Brain Metastases-a Single-Center Study in 190 Patients.

Kündig, Alexandra; Zens, Philipp; Fung, Christian; Scherz, Amina; Cerciello, Ferdinando; Herrmann, Evelyn; Ermis, Ekin; Schmid, Ralph A; Vassella, Erik; Berezowska, Sabina (2022). Programmed Death-Ligand 1 Expression in Lung Cancer and Paired Brain Metastases-a Single-Center Study in 190 Patients. JTO clinical and research reports, 3(11), p. 100413. 10.1016/j.jtocrr.2022.100413

[img]
Preview
Text
1-s2.0-S2666364322001370-main.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

Introduction

Expression of programmed death-ligand 1 (PD-L1) is the only routinely used tissue biomarker for predicting response to programmed cell death protein 1/PD-L1 inhibitors. It is to date unclear whether PD-L1 expression is preserved in brain metastases (BMs).

Methods

In this single-center, retrospective study, we evaluated PD-L1 expression using the SP263 assay in consecutively resected BMs of lung carcinomas and paired primary tumors, diagnosed from 2000 to 2015, with correlation to clinicopathological and molecular tumor and patient characteristics.

Results

PD-L1 tumor proportional score (TPS) could be evaluated on whole tissue slides in 191 BMs and 84 paired primary lung carcinomas. PD-L1 TPS was less than 1% in 113 of 191 (59.2%), 1% to 49% in 34 of 191 (17.8%), and greater than or equal to 50% in 44 of 191 (23.0%) BMs. TPS was concordant between BMs and paired primary lung carcinomas in most cases, with discordance regarding the clinically relevant cutoffs at 1% and 50% in 18 of 84 patients (21.4%). Four of 18 discordant cases had no shared mutations between the primary lung carcinoma and BM. Intratumoral heterogeneity, as assessed using tissue microarray cores, was only significant at the primary site (p Wilcoxon signed rank = 0.002) with higher PD-L1 TPS at the infiltration front (mean = 40.4%, interquartile range: 0%-90%). Neither TPS greater than or equal to 1% nor TPS greater than or equal to 50% nor discordance between the primary lung carcinoma and BMs had prognostic significance regarding overall survival or BM-specific overall survival.

Conclusions

PD-L1 expression was mostly concordant between primary lung carcinoma and its BM and between resections of BM and stereotactic biopsies, mirrored by tissue microarray cores. Differences in PD-L1 TPS existed primarily in cases with TPS greater than 10%, for which also human assessment tends to be most error prone.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Tumour Pathology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Kündig, Alexandra Gabriela; Zens, Philipp Immanuel; Fung, Christian; Scherz, Amina; Cerciello, Ferdinando; Herrmann, Evelyn; Ermis, Ekin; Schmid, Ralph; Vassella, Erik and Berezowska, Sabina Anna

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2666-3643

Language:

English

Submitter:

Pubmed Import

Date Deposited:

25 Oct 2022 10:00

Last Modified:

05 Dec 2022 16:26

Publisher DOI:

10.1016/j.jtocrr.2022.100413

PubMed ID:

36275910

Uncontrolled Keywords:

Brain metastasis Immune checkpoint inhibitors Lung cancer NSCLC PD-L1

BORIS DOI:

10.48350/174062

URI:

https://boris.unibe.ch/id/eprint/174062

Actions (login required)

Edit item Edit item
Provide Feedback