Gigon, Lea; Fettrelet, Timothée; Yousefi, Shida; Simon, Dagmar; Simon, Hans-Uwe (2023). Eosinophils from A to Z. Allergy, 78(7), pp. 1810-1846. Wiley 10.1111/all.15751
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Allergy_-_2023_-_Gigon_-_Eosinophils_from_A_to_Z.pdf - Accepted Version Available under License Publisher holds Copyright. Download (4MB) | Preview |
Eosinophils are bone marrow-derived granulocytes and are found in low numbers in the peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the bone marrow is increased, resulting in a rise in the number of mature eosinophils released in the circulation. From the blood, eosinophils can migrate in multiple tissues and organs under both physiological and pathological conditions. Eosinophils exert their various functions through the synthesis and release of a variety of granule proteins and pro-inflammatory mediators. Despite being present in all species of vertebrates, the functional role of eosinophils is still a matter of debate. Eosinophils may play a role in host defense against various pathogens. In addition, eosinophils have been reported to be involved in tissue homeostasis and exhibit immunomodulatory activities. In this review, we aim to provide a broad overview of eosinophil biology and eosinophilic diseases in a lexicon-style format using keywords starting from A until Z with crossreferences to other chapters indicated in italic in the text or specified in parentheses.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Gigon, Lea, Fettrelet, Timothée Louis, Yousefi, Shida, Simon, Dagmar, Simon, Hans-Uwe |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1398-9995 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 Apr 2023 10:31 |
Last Modified: |
28 Apr 2024 00:25 |
Publisher DOI: |
10.1111/all.15751 |
PubMed ID: |
37102676 |
Uncontrolled Keywords: |
eosinophil eosinophil subsets eosinopoiesis immunoregulation tissue homeostasis |
BORIS DOI: |
10.48350/182048 |
URI: |
https://boris.unibe.ch/id/eprint/182048 |
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