Lung-on-a-Chip Models of the Lung Parenchyma.

Zamprogno, Pauline; Schulte, Jan; Ferrari, Dario; Rechberger, Karin; Sengupta, Arunima; van Os, Lisette; Weber, Tobias; Zeinali, Soheila; Geiser, Thomas; Guenat, Olivier T. (2023). Lung-on-a-Chip Models of the Lung Parenchyma. Advances in experimental medicine and biology, 1413, pp. 191-211. Springer 10.1007/978-3-031-26625-6_10

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Since the publication of the first lung-on-a-chip in 2010, research has made tremendous progress in mimicking the cellular environment of healthy and diseased alveoli. As the first lung-on-a-chip products have recently reached the market, innovative solutions to even better mimic the alveolar barrier are paving the way for the next generation lung-on-chips. The original polymeric membranes made of PDMS are being replaced by hydrogel membranes made of proteins from the lung extracellular matrix, whose chemical and physical properties exceed those of the original membranes. Other aspects of the alveolar environment are replicated, such as the size of the alveoli, their three-dimensional structure, and their arrangement. By tuning the properties of this environment, the phenotype of alveolar cells can be tuned, and the functions of the air-blood barrier can be reproduced, allowing complex biological processes to be mimicked. Lung-on-a-chip technologies also provide the possibility of obtaining biological information that was not possible with conventional in vitro systems. Pulmonary edema leaking through a damaged alveolar barrier and barrier stiffening due to excessive accumulation of extracellular matrix proteins can now be reproduced. Provided that the challenges of this young technology are overcome, there is no doubt that many application areas will benefit greatly.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Organs-on Chip Technologies
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Zamprogno, Pauline Gil Véronique, Schulte, Jan Andries, Ferrari, Dario, Rechberger, Karin Farah, Sengupta, Arunima, van Os, Lisette, Weber, Tobias Adrian, Zeinali, Soheila, Geiser, Thomas (A), Guenat, Olivier Thierry

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0065-2598

Publisher:

Springer

Language:

English

Submitter:

Pubmed Import

Date Deposited:

19 May 2023 12:29

Last Modified:

28 Dec 2023 09:39

Publisher DOI:

10.1007/978-3-031-26625-6_10

PubMed ID:

37195532

Uncontrolled Keywords:

Alveolar cells Alveolar microenvironment COVID Lung diseases Lung in-vitro model Microfluidics Organs-on-chip

BORIS DOI:

10.48350/182666

URI:

https://boris.unibe.ch/id/eprint/182666

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