Blacksell, Stuart D.; Dhawan, Sandhya; Kusumoto, Marina; Le, Kim Khanh; Summermatter, Kathrin; O'Keefe, Joseph; Kozlovac, Joseph; Almuhairi, Salama Suhail; Sendow, Indrawati; Scheel, Christina M.; Ahumibe, Anthony; Masuku, Zibusiso M.; Kojima, Kazunobu; Harper, David R.; Hamilton, Keith (2023). The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—SARS-CoV-2. Applied biosafety, 28(2), pp. 87-95. Mary Ann Liebert 10.1089/apb.2022.0039
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Introduction: The SARS-CoV-2 virus emerged as a novel virus and is the causative agent of the COVID-19 pandemic. It spreads readily human-to-human through droplets and aerosols. The Biosafety Research Roadmap aims to support the application of laboratory biological risk management by providing an evidence base for biosafety measures. This involves assessing the current biorisk management evidence base, identifying research and capability gaps, and providing recommendations on how an evidence-based approach can support biosafety and biosecurity, including in low-resource settings.
Methods: A literature search was conducted to identify potential gaps in biosafety and focused on five main sections, including the route of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination strategies.
Results: There are many knowledge gaps related to biosafety and biosecurity due to the SARS-CoV-2 virus's novelty, including infectious dose between variants, personal protective equipment for personnel handling samples while performing rapid diagnostic tests, and laboratory-acquired infections. Detecting vulnerabilities in the biorisk assessment for each agent is essential to contribute to the improvement and development of laboratory biosafety in local and national systems.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Virology |
UniBE Contributor: |
Summermatter, Kathrin |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1535-6760 |
Publisher: |
Mary Ann Liebert |
Language: |
English |
Submitter: |
Katharina Summermatter |
Date Deposited: |
14 Jun 2023 07:55 |
Last Modified: |
14 Jun 2023 08:05 |
Publisher DOI: |
10.1089/apb.2022.0039 |
BORIS DOI: |
10.48350/183390 |
URI: |
https://boris.unibe.ch/id/eprint/183390 |
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