The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—SARS-CoV-2

Blacksell, Stuart D.; Dhawan, Sandhya; Kusumoto, Marina; Le, Kim Khanh; Summermatter, Kathrin; O'Keefe, Joseph; Kozlovac, Joseph; Almuhairi, Salama Suhail; Sendow, Indrawati; Scheel, Christina M.; Ahumibe, Anthony; Masuku, Zibusiso M.; Kojima, Kazunobu; Harper, David R.; Hamilton, Keith (2023). The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—SARS-CoV-2. Applied biosafety, 28(2), pp. 87-95. Mary Ann Liebert 10.1089/apb.2022.0039

[img]
Preview
Text
apb.2022.0039.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (223kB) | Preview

Introduction: The SARS-CoV-2 virus emerged as a novel virus and is the causative agent of the COVID-19 pandemic. It spreads readily human-to-human through droplets and aerosols. The Biosafety Research Roadmap aims to support the application of laboratory biological risk management by providing an evidence base for biosafety measures. This involves assessing the current biorisk management evidence base, identifying research and capability gaps, and providing recommendations on how an evidence-based approach can support biosafety and biosecurity, including in low-resource settings.

Methods: A literature search was conducted to identify potential gaps in biosafety and focused on five main sections, including the route of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination strategies.

Results: There are many knowledge gaps related to biosafety and biosecurity due to the SARS-CoV-2 virus's novelty, including infectious dose between variants, personal protective equipment for personnel handling samples while performing rapid diagnostic tests, and laboratory-acquired infections. Detecting vulnerabilities in the biorisk assessment for each agent is essential to contribute to the improvement and development of laboratory biosafety in local and national systems.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Virology

UniBE Contributor:

Summermatter, Kathrin

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1535-6760

Publisher:

Mary Ann Liebert

Language:

English

Submitter:

Katharina Summermatter

Date Deposited:

14 Jun 2023 07:55

Last Modified:

08 May 2024 11:40

Publisher DOI:

10.1089/apb.2022.0039

PubMed ID:

37342515

BORIS DOI:

10.48350/183390

URI:

https://boris.unibe.ch/id/eprint/183390

Actions (login required)

Edit item Edit item
Provide Feedback