Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs

Gottstein, Bruno; Wittwer, Matthias; Schild, Marc; Merli, Michael; Leib, Stephen L.; Müller, Norbert; Müller, Joachim; Jaggi, Rolf (2010). Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs. PLoS ONE, 5(4), e9779. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0009779

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Alveolar echinococcosis (AE) is a severe chronic hepatic parasitic disease currently emerging in central and eastern Europe. Untreated AE presents a high mortality (>90%) due to a severe hepatic destruction as a result of parasitic metacestode proliferation which behaves like a malignant tumor. Despite this severe course and outcome of disease, the genetic program that regulates the host response leading to organ damage as a consequence of hepatic alveolar echinococcosis is largely unknown.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pathologie > Forschungsgruppe Molekularbiologie

UniBE Contributor:

Leib, Stephen; Müller, Norbert; Müller, Heinz Joachim and Jaggi, Rolf

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

17 Dec 2014 21:45

Publisher DOI:

10.1371/journal.pone.0009779

PubMed ID:

20368974

Web of Science ID:

000276418200003

BORIS DOI:

10.7892/boris.287

URI:

https://boris.unibe.ch/id/eprint/287 (FactScience: 197363)

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