Endogenous and synthetic MMP inhibitors in CNS physiopathology.

Baranger, Kévin; Rivera, Santiago; Liechti, Fabian D; Grandgirard, Denis; Bigas, Judit; Seco, Jesús; Tarrago, Teresa; Leib, Stephen; Khrestchatisky, Michel (2014). Endogenous and synthetic MMP inhibitors in CNS physiopathology. In: Dityatev, Alexander; Wehrle-Haller, Bernhard; Pitkänen, Asla (eds.) Brain Extracellular Matrix in Health and Disease. Progress in Brain Research: Vol. 214 (pp. 313-351). Elsevier 10.1016/B978-0-444-63486-3.00014-1

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Matrix metalloproteinases (MMPs, including the membrane-type MMPs (MT-MMPs)), a disintegrin and metalloproteinase (ADAM), and ADAM with thrombospondin motifs belong to the metzincins, a subclass of metalloproteinases that contain a Met residue and a Zn(2+) ion at the catalytic site necessary for enzymatic reaction. MMP proteolytic activity is mainly controlled by their natural tissue inhibitors of metalloproteinase (TIMP). A number of synthetic inhibitors have been developed to control deleterious MMP activity. The roles of MMPs and some of their ECM substrates in CNS physiology and pathology are covered by other chapters of the present volume and will thus not be addressed in depth. This chapter will focus (i) on the endogenous MMP inhibitors in the CNS, (ii) on MMP and TIMP regulations in three large classes of neuropathologic processes (inflammatory, neurodegenerative, and infectious), and (iii) on synthetic inhibitors of MMPs and the perspective of their use in different brain diseases.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Grandgirard, Denis and Leib, Stephen

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1875-7855

ISBN:

978-0-444-63486-3

Series:

Progress in Brain Research

Publisher:

Elsevier

Funders:

[UNSPECIFIED] COST Action BM1001 “Brain Extracellular Matrix in Health and Disease”
[4] Swiss National Science Foundation

Language:

English

Submitter:

Stephen Leib

Date Deposited:

06 Feb 2015 16:42

Last Modified:

08 Feb 2017 13:46

Publisher DOI:

10.1016/B978-0-444-63486-3.00014-1

PubMed ID:

25410364

Uncontrolled Keywords:

Alzheimer's disease, EAE, Synthetic MMP inhibitors, bacterial meningitis, multiple sclerosis

BORIS DOI:

10.7892/boris.61933

URI:

https://boris.unibe.ch/id/eprint/61933

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