Computer planned, image-guided combined resection and ablation for bilobar colorectal liver metastases

Banz Wüthrich, Vanessa; Bächtold, Matthias; Weber, Stefan; Peterhans, Matthias; Inderbitzin, Daniel; Candinas, Daniel (2014). Computer planned, image-guided combined resection and ablation for bilobar colorectal liver metastases. World journal of gastroenterology, 20(40), pp. 14992-14996. WJG Press 10.3748/wjg.v20.i40.14992

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For patients with extensive bilobar colorectal liver metastases (CRLM), initial surgery may not be feasible and a multimodal approach including microwave ablation (MWA) provides the only chance for prolonged survival. Intraoperative navigation systems may improve the accuracy of ablation and surgical resection of so-called "vanishing lesions", ultimately improving patient outcome. Clinical application of intraoperative navigated liver surgery is illustrated in a patient undergoing combined resection/MWA for multiple, synchronous, bilobar CRLM. Regular follow-up with computed tomography (CT) allowed for temporal development of the ablation zones. Of the ten lesions detected in a preoperative CT scan, the largest lesion was resected and the others were ablated using an intraoperative navigation system. Twelve months post-surgery a new lesion (Seg IVa) was detected and treated by trans-arterial embolization. Nineteen months post-surgery new liver and lung metastases were detected and a palliative chemotherapy started. The patient passed away four years after initial diagnosis. For patients with extensive CRLM not treatable by standard surgery, navigated MWA/resection may provide excellent tumor control, improving longer-term survival. Intraoperative navigation systems provide precise, real-time information to the surgeon, aiding the decision-making process and substantially improving the accuracy of both ablation and resection. Regular follow-ups including 3D modeling allow for early discrimination between ablation zones and recurrent tumor lesions.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Image Guided Therapy
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Banz Wüthrich, Vanessa; Bächtold, Matthias; Weber, Stefan; Peterhans, Matthias; Inderbitzin, Daniel and Candinas, Daniel

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1007-9327

Publisher:

WJG Press

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

20 Mar 2015 13:13

Last Modified:

10 Jan 2017 17:10

Publisher DOI:

10.3748/wjg.v20.i40.14992

PubMed ID:

25356061

Uncontrolled Keywords:

Colorectal liver metastases; Computer navigation; Image-guidance; Microwave ablation; Tumor

BORIS DOI:

10.7892/boris.65337

URI:

https://boris.unibe.ch/id/eprint/65337

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