High Prevalence of Extended-Spectrum β-Lactamase, Plasmid-Mediated AmpC and Carbapenemase genes in Food for Pets

Seiffert, Salome Nadja; Carattoli, Alessandra; Tinguely, Regula; Lupo, Agnese; Perreten, Vincent; Endimiani, Andrea (2014). High Prevalence of Extended-Spectrum β-Lactamase, Plasmid-Mediated AmpC and Carbapenemase genes in Food for Pets. Antimicrobial agents and chemotherapy, 58(10), pp. 6320-6323. American Society for Microbiology 10.1128/AAC.03185-14

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We evaluated the pet food contained in thirty packages as potential origin of extended-spectrum cephalosporin-resistant Gram-negative organisms and β-lactamase genes (bla). Alive bacteria were not detected by selective culture. However, PCR investigations on food DNA extracts indicated that samples harbored blaCTX-M-15 (53.3%), blaCMY-4 (20%), and blaVEB-4-like (6.7%). Particularly worrisome was the presence of blaOXA-48-like carbapenemases (13.3%). Original pet food ingredients and/or the production process were highly contaminated with bacteria carrying clinically relevant acquired bla genes.

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