Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells

Federzoni, Elena; Gloor, Severin; Jin, Jing; Krauer, Deborah; Fey, Martin; Torbett, Bruce E; Tschan, Mario (2015). Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells. Leukemia research reports, 4(1), pp. 32-35. Elsevier 10.1016/j.lrr.2015.04.002

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In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil samples. SENP5 is an enzyme that targets and cleaves small ubiquitin-like modifier (SUMO) residues from SUMOylated proteins. Further investigation with AML neutrophil differentiation cell models showed increased SENP5 expression upon induction of differentiation; in contrast, knocking down SENP5 resulted in significantly attenuated neutrophil differentiation. Our results support a new role of SENP5 in AML pathology, and in particular in the neutrophil differentiation of myeloid leukemic cells.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Tumour Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Med. Onkologie / Hämatologie (Erw.)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Med. Onkologie / Hämatologie (Erw.)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Federzoni, Elena; Jin, Jing; Krauer, Deborah; Fey, Martin and Tschan, Mario

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2213-0489

Publisher:

Elsevier

Language:

English

Submitter:

Doris Haefelin

Date Deposited:

14 Jul 2015 13:58

Last Modified:

20 Aug 2018 15:27

Publisher DOI:

10.1016/j.lrr.2015.04.002

PubMed ID:

25984443

Uncontrolled Keywords:

AML; Acute myeloid leukemia; Neutrophil differentiation; SENP5; SUMO protease

BORIS DOI:

10.7892/boris.70313

URI:

https://boris.unibe.ch/id/eprint/70313

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