New insights on the role of paired membrane structures in coronavirus replication.

V'Kovski, Philip; Al-Mulla, Hawaa; Thiel, Volker Earl; Neuman, Benjamin W (2015). New insights on the role of paired membrane structures in coronavirus replication. Virus research, 202, pp. 33-40. Elsevier 10.1016/j.virusres.2014.12.021

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The replication of coronaviruses, as in other positive-strand RNA viruses, is closely tied to the formation of membrane-bound replicative organelles inside infected cells. The proteins responsible for rearranging cellular membranes to form the organelles are conserved not just among the Coronaviridae family members, but across the order Nidovirales. Taken together, these observations suggest that the coronavirus replicative organelle plays an important role in viral replication, perhaps facilitating the production or protection of viral RNA. However, the exact nature of this role, and the specific contexts under which it is important have not been fully elucidated. Here, we collect and interpret the recent experimental evidence about the role and importance of membrane-bound organelles in coronavirus replication.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

V'Kovski, Philip and Thiel, Volker Earl

Subjects:

600 Technology > 630 Agriculture

ISSN:

0168-1702

Publisher:

Elsevier

Language:

English

Submitter:

Barbara Gautschi-Steffen

Date Deposited:

24 Mar 2016 16:05

Last Modified:

24 Mar 2016 16:05

Publisher DOI:

10.1016/j.virusres.2014.12.021

PubMed ID:

25550072

Uncontrolled Keywords:

Membrane rearrangement; RNA virus replication; Replicative organelle; Virus factory

BORIS DOI:

10.7892/boris.76859

URI:

https://boris.unibe.ch/id/eprint/76859

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