Double Copies of bla(KPC-3)::Tn4401a on an IncX3 Plasmid in Klebsiella pneumoniae Successful Clone ST512 from Italy.

Fortini, Daniela; Villa, Laura; Feudi, Claudia; Do Couto Pires, Joao Pedro; Bonura, Celestino; Mammina, Caterina; Endimiani, Andrea; Carattoli, Alessandra (2016). Double Copies of bla(KPC-3)::Tn4401a on an IncX3 Plasmid in Klebsiella pneumoniae Successful Clone ST512 from Italy. Antimicrobial agents and chemotherapy, 60(1), pp. 646-649. American Society for Microbiology 10.1128/AAC.01886-15

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A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla(KPC) genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla(KPC-3) gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla(KPC-3)::Tn4401a caused by intramolecular transposition events were detected in the plasmid.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Do Couto Pires, Joao Pedro; Endimiani, Andrea and Carattoli, Alessandra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Funders:

[4] Swiss National Science Foundation

Projects:

[577] SNF project 153377 to Andrea Endimiani

Language:

English

Submitter:

Andrea Endimiani

Date Deposited:

02 May 2016 15:43

Last Modified:

13 Sep 2017 06:27

Publisher DOI:

10.1128/AAC.01886-15

PubMed ID:

26525794

BORIS DOI:

10.7892/boris.81548

URI:

https://boris.unibe.ch/id/eprint/81548

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