Fatal Outcome of Tick-borne Encephalitis after Vaccine Failure

Sendi, Parham; Hirzel, Cédric; Pfister, Stefan; Ackermann-Gäumann, Rahel; Grandgirard, Denis; Hewer, Ekkehard; Nirkko, Arto Christian (2017). Fatal Outcome of Tick-borne Encephalitis after Vaccine Failure. Frontiers in neurology, 8(119) Frontiers Media S.A. 10.3389/fneur.2017.00119

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Tick-borne encephalitis is a viral disease affecting the central nervous system. It is endemic in Switzerland with 200 to 250 notified cases annually. Active immunization is effective for persons in all age groups. Vaccine failure is rare, in particular after a completed vaccination course. Here, we describe the case of 67-year-old man with a fatal outcome despite vaccination. The diagnosis was confirmed by extensive postmortem analyses. The diagnostic challenges of vaccine failure in tick-borne encephalitis and the dynamics of the immune response in vaccination breakthrough are discussed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
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04 Faculty of Medicine > Other Institutions > Teaching Staff, Faculty of Medicine
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Sendi, Parham; Hirzel, Cédric; Pfister, Stefan; Grandgirard, Denis; Hewer, Ekkehard and Nirkko, Arto Christian

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1664-2295

Publisher:

Frontiers Media S.A.

Language:

English

Submitter:

Ekkehard Hewer

Date Deposited:

20 Apr 2017 13:21

Last Modified:

25 Apr 2017 14:18

Publisher DOI:

10.3389/fneur.2017.00119

BORIS DOI:

10.7892/boris.97585

URI:

https://boris.unibe.ch/id/eprint/97585

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