Effect of smoking on survival of patients with hepatocellular carcinoma.

Kolly, Philippe; Knöpfli, Marina Janusheva; Dufour, Jean-François (2017). Effect of smoking on survival of patients with hepatocellular carcinoma. Liver international, 37(11), pp. 1682-1687. Wiley 10.1111/liv.13466

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BACKGROUND & AIMS

Lifestyle factors such as smoking, obesity and physical activity have gained interest in the field of hepatocellular carcinoma. These factors play a significant role in the development of hepatocellular carcinoma. Several studies revealed the impact of tobacco consumption on the development of hepatocellular carcinoma and its synergistic effects with viral etiologies (hepatitis B and C). The effects of smoking on survival in patients with a diagnosed hepatocellular carcinoma have not yet been investigated in a Western cohort where hepatitis C infection is a major risk factor.

METHODS

Using data from a prospective cohort of patients with hepatocellular carcinoma who were followed at the University Hospital of Bern, Switzerland, survival was compared by Kaplan-Meier analysis in smokers and nonsmokers, and multivariate Cox regression was applied to control for confounding variables.

RESULTS

Of 238 eligible hepatocellular carcinoma patients, 64 were smokers at the time of inclusion and 174 were nonsmokers. Smokers had a significant worse overall survival than nonsmokers (hazard ratio 1.77, 95% confidence interval: 1.22-2.58, P=.003). Analysis of patients according to their underlying liver disease, revealed that smoking, and not nonsmoking, affected survival of hepatitis B virus and C virus-infected patients only. In this subgroup, smoking was an independent predictor for survival (hazard ratio 2.99, 95% confidence interval: 1.7-5.23, P<.001) and remained independently predictive when adjusted for confounding variables.

CONCLUSIONS

This study shows that smoking is an independent predictor of survival in hepatitis B virus/hepatitis C virus-infected patients with hepatocellular carcinoma.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

Graduate School:

 Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

 Kolly, Philippe (A), Knöpfli, Marina Janusheva, Dufour, Jean-François

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 1478-3231

Publisher:

 Wiley

Language:

 English

Submitter:

 Thi Thao Anh Pham

Date Deposited:

 31 Jan 2018 16:07

Last Modified:

 29 Mar 2023 23:35

Publisher DOI:

 10.1111/liv.13466

PubMed ID:

 28467657

Uncontrolled Keywords:

 hepatitis B virus hepatitis C virus hepatocellular carcinoma smoking survival

BORIS DOI:

 10.7892/boris.107126

URI:

 https://boris.unibe.ch/id/eprint/107126

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