No Effect of Pegylated Interferon-alpha on Total Hiv-1 DNA Load in HIV-1/HCV Coinfected Patients.

Strouvelle, Victoria P; Braun, Dominique L; Vongrad, Valentina; Scherrer, Alexandra U; Kok, Yik Lim; Kouyos, Roger D; Stöckle, Marcel; Rauch, Andri; Darling, Katharine; Hoffmann, Matthias; Metzner, Karin J; Günthard, Huldrych F (2018). No Effect of Pegylated Interferon-alpha on Total Hiv-1 DNA Load in HIV-1/HCV Coinfected Patients. Journal of infectious diseases, 217(12), pp. 1883-1888. Oxford University Press 10.1093/infdis/jiy131

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Pegylated interferon-alpha (pIFN-α) is suggested to lower HIV-1 DNA load in antiretroviral therapy (ART) treated patients. We studied the kinetics of total HIV-1 DNA levels in 40 HIV-1/hepatitis C (HCV) coinfected patients, treated with pIFN-α for HCV and categorized into three groups according to start of ART: Chronic HIV-1 infection (n=22), acute HIV-1 infection (n=8), no-ART (n=10). Total HIV-1 DNA levels were quantified in 247 PBMC samples and remained stable before, during, and after pIFN-α treatment in all three groups. Our study-results question the benefit of pIFN-α as an immunotherapeutic agent for reducing the HIV-1 reservoir.

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