Ruegg, Gion; Luethi, Nora; Cioccari, Luca (20 July 2021). The Role of Dexmedetomidine for the Prevention of Acute Kidney Injury in Critical Care. European Medical Journal Nephrology, 9(1), pp. 97-106. European Medical Group
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Abstract
Acute kidney injury (AKI) occurs in up to 50% of patients admitted to the intensive care unit and is associated with increased mortality. Currently, there is no effective pharmacotherapy for
prevention or treatment of AKI. In animal models of sepsis and ischaemia-reperfusion, α2-agonists like dexmedetomidine (DEX) exhibit anti-inflammatory properties and experimental data indicate a potential protective effect of DEX on renal function. However, clinical trials have yielded inconsistent results in critically ill patients. This review discusses the pathophysiological mechanisms involved in AKI, the renal effects of DEX in various intensive care unit-related conditions, and summarises the available literature addressing the use of DEX for the prevention of AKI.
Item Type: |
Conference or Workshop Item (Paper) |
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Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care |
UniBE Contributor: |
Rüegg, Gion, Lüthi, Nora, Cioccari, Luca (A) |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2053-4248 |
Publisher: |
European Medical Group |
Language: |
English |
Submitter: |
Isabelle Arni |
Date Deposited: |
13 Aug 2021 13:24 |
Last Modified: |
29 Mar 2023 23:37 |
BORIS DOI: |
10.48350/157896 |
URI: |
https://boris.unibe.ch/id/eprint/157896 |
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