Rhabdoviruses as Vaccine Vectors for Veterinary Pathogens

Zimmer, Gert (2021). Rhabdoviruses as Vaccine Vectors for Veterinary Pathogens. In: Vanniasinkam, Thiru; Tikoo, Suresh K.; Samal, Siba K. (eds.) Viral Vectors in Veterinary Vaccine Development: A Textbook (pp. 141-148). Springer 10.1007/978-3-030-51927-8_9

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Rhabdoviruses are simple RNA viruses, which are open to genetic manipulation. Recombinant vector vaccines based on vesicular stomatitis virus (VSV) or rabies virus (RABV) are capable of inducing strong and protective immune responses in animals and humans as exemplified by the VSV-based Ebola virus vaccine. As several rhabdoviruses are harmful for animals and/or humans, the recombinant vector vaccine derived from them needs to be properly attenuated. Single-cycle vector vaccines and interferon-stimulating viruses represent attractive strategies to achieve attenuation. VSV and RABV are notifiable Office International des Epizooties (OIE)-listed pathogens, and this has impeded their general use in the veterinary field. However, vector vaccines based on different non-notifiable rhabdoviruses may represent an attractive alternative.

Item Type:

Book Section (Book Chapter)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology

UniBE Contributor:

Zimmer, Gert

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISBN:

978-3-030-51927-8

Publisher:

Springer

Language:

English

Submitter:

Pamela Schumacher

Date Deposited:

18 Nov 2021 10:43

Last Modified:

05 Dec 2022 15:54

Publisher DOI:

10.1007/978-3-030-51927-8_9

Uncontrolled Keywords:

Vesicular stomatitis virus Rabies virus Attenuation Pathogenicity Interferon Chimeric virus Pseudotyping Single-cycle vector

BORIS DOI:

10.48350/160720

URI:

https://boris.unibe.ch/id/eprint/160720

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