Müller, Annelies; Kleynhans, Jackie; de Gouveia, Linda; Meiring, Susan; Cohen, Cheryl; Hathaway, Lucy Jane; von Gottberg, Anne (2022). Streptococcus pneumoniae Serotypes Associated with Death, South Africa, 2012-2018. Emerging infectious diseases, 28(1), pp. 166-179. Centers for Disease Control and Prevention 10.3201/eid2801.210956
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The Streptococcus pneumoniae polysaccharide capsule plays a role in disease severity. We assessed the association of serotype with case-fatality ratio (CFR) in invasive pneumococcal disease (IPD) and meningitis in South Africa, 2012-2018 (vaccine era), using multivariable logistic regression by manual backward elimination. The most common serotypes causing IPD were 8 and 19A. In patients <15 years of age, serotypes associated with increased CFR in IPD, compared with serotype 8 and controlling for confounding factors, were 11A, 13, 19F, 15A, and 6A. None of these serotypes were associated with increased CFR in meningitis. Among IPD patients >15 years of age, serotype 15B/C was associated with increased CFR. Among meningitis patients of all ages, serotype 1 was associated with increased CFR. PCV13 serotypes 1, 3, 6A, 19A, and 19F should be monitored, and serotypes 8, 12F, 15A, and 15B/C should be considered for inclusion in vaccines to reduce deaths caused by S. pneumoniae.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Müller, Annelies Kathrin, Hathaway, Lucy Jane |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1080-6059 |
Publisher: |
Centers for Disease Control and Prevention |
Funders: |
[UNSPECIFIED] Swiss-South African Joint Research Programme, SNSF & NRF |
Language: |
English |
Submitter: |
Lucy Jane Hathaway |
Date Deposited: |
24 Jan 2022 14:06 |
Last Modified: |
05 Dec 2022 16:03 |
Publisher DOI: |
10.3201/eid2801.210956 |
PubMed ID: |
34932448 |
Additional Information: |
Lucy Jane Hathaway and Anne von Gottberg contributed equally to this article. |
Uncontrolled Keywords: |
South Africa; Streptococcus; Streptococcus pneumoniae; Switzerland; bacteria; case-fatality ratio; meningitis/encephalitis; mortality; polysaccharide capsule; serotype; streptococci. |
BORIS DOI: |
10.48350/164351 |
URI: |
https://boris.unibe.ch/id/eprint/164351 |
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