Sendi, Parham; Thierstein, Marc; Widmer, Nadja; Babongo Bosombo, Flora; Büchi, Annina Elisabeth; Güntensperger, Dominik; Blum, Manuel Raphael; Baldan, Rossella; Tinguely, Caroline; Gahl, Brigitta; Heg, Dik; Theel, Elitza S.; Berbari, Elie; Endimiani, Andrea; Gowland, Peter; Niederhauser, Christoph (2022). Serosurveillance after a COVID-19 Vaccine Campaign in a Swiss Police Cohort. Immunity, inflammation and disease, 10(7), e640. Wiley 10.1002/iid3.640
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Immunity_Inflam_Disease_-_2022_-_Sendi_-_Serosurveillance_after_a_COVID_19_vaccine_campaign_in_a_Swiss_police_cohort.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
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PoliCOV-19_second_manuscript_final.pdf - Accepted Version Available under License Creative Commons: Attribution (CC-BY). Download (972kB) | Preview |
Introduction: To assess the risk for COVID-19 of police officers, we are studying the seroprevalence in a cohort. The baseline cross-sectional investigation was performed prior to a vaccination campaign in January/February 2021, and demonstrated a seroprevalence of 12.9%. Here, we demonstrate serosurveillance results after a vaccination campaign.
Methods: The cohort consists of 1022 study participants. The 3-month and 6-month follow-up visits were performed in April/May and September 2021. Data on infection and vaccination rates were obtained via measuring antibodies to the nucleocapsid protein and spike protein and online questionnaires.
Results: The mean age of the population was 41 (SD 8.8) years, 72% were male and 76% had no comorbidity. Seroconversion was identified in 1.05% of the study population at the 3-month visit and in 0.73% at the 6-month visit, resulting in an infection rate of 1.8% over a time period of 6 months. In comparison, the infection rate in the general population over the same time period was higher (3.18%, P=0.018). At the 6-month visit, 77.8% of participants reported being vaccinated once and 70.5% twice; 81% had an anti-S antibody titer of >250 U/mL and 87.1% of ≥2 U/mL. No significant association between infection and job role within the department, working region, or years of experience in the job was found. Anti-spike antibody titers of vaccinated study participants showed a calculated decreasing trend 150 to 200 days after the second vaccine dose.
Conclusion: These data confirm the value of the vaccination campaign in an exposed group other than healthcare professionals.
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