Brogli, Rebecca; Cristodero, Marina; Schneider, André; Polacek, Norbert (2023). A ribosome-bound tRNA half stimulates mitochondrial translation during stress recovery in Trypanosoma brucei. Cell reports, 42(9), p. 113112. Cell Press 10.1016/j.celrep.2023.113112
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The protozoan parasite Trypanosoma brucei and its disease-causing relatives are among the few organisms that barely regulate the transcription of protein-coding genes. Yet, alterations in its gene expression are essential to survive in different host environments. Recently, tRNA-derived RNAs have been implicated as regulators of many cellular processes within and beyond translation. Previously, we identified the tRNAThr-3'-half (AGU) as a ribosome-associated non-coding RNA able to enhance global translation. Here we report that the tRNAThr-3'-half is generated upon starvation inside the mitochondria. The tRNAThr-3'-half associates with mitochondrial ribosomes and stimulates translation during stress recovery, positively affecting mitochondrial activity and, consequently, cellular energy production capacity. Our results describe an organelle ribosome-associated ncRNA involved in translation regulation to boost the central hub of energy metabolism as an immediate stress recovery response.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Brogli, Rebecca, Cristodero, Marina, Schneider, André, Polacek, Norbert |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
2211-1247 |
Publisher: |
Cell Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
15 Sep 2023 08:20 |
Last Modified: |
05 Oct 2023 00:15 |
Publisher DOI: |
10.1016/j.celrep.2023.113112 |
PubMed ID: |
37703180 |
Uncontrolled Keywords: |
CP: Microbiology CP: Molecular biology mitochondria mitoribosome protein synthesis stress response tRNA fragment tRNA half translation regulation |
BORIS DOI: |
10.48350/186309 |
URI: |
https://boris.unibe.ch/id/eprint/186309 |
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