SARS-CoV-2 biology and host interactions.

Steiner, Silvio; Kratzel, Annika; Barut, G Tuba; Lang, Reto M; Aguiar Moreira, Etori; Thomann, Lisa; Kelly, Jenna N; Thiel, Volker (2024). SARS-CoV-2 biology and host interactions. Nature reviews. Microbiology, 22(4), pp. 206-225. Springer Nature 10.1038/s41579-023-01003-z

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The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected our society. The rapid spread and continuous evolution of new SARS-CoV-2 variants continue to threaten global public health. Recent scientific advances have dissected many of the molecular and cellular mechanisms involved in coronavirus infections, and large-scale screens have uncovered novel host-cell factors that are vitally important for the virus life cycle. In this Review, we provide an updated summary of the SARS-CoV-2 life cycle, gene function and virus-host interactions, including recent landmark findings on general aspects of coronavirus biology and newly discovered host factors necessary for virus replication.

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