Usemann, Jakob; Mozun, Rebeca; Kuehni, Claudia E; de Hoogh, Kees; Flueckiger, Benjamin; Singer, Florian; Zwahlen, Marcel; Moeller, Alexander; Latzin, Philipp (2024). Air pollution exposure during pregnancy and lung function in childhood: The LUIS study. (In Press). Pediatric pulmonology Wiley 10.1002/ppul.27169
|
Text
Pediatric_Pulmonology_-_2024_-_Usemann_-_Air_pollution_exposure_during_pregnancy_and_lung_function_in_childhood__The_LUIS.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (922kB) | Preview |
|
|
Text
Usemann_PediatrPulmonol_2024_supplmat.pdf - Supplemental Material Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (818kB) | Preview |
BACKGROUND
The adverse effects of high air pollution levels on childhood lung function are well-known. Limited evidence exists on the effects of moderate exposure levels during early life on childhood lung function. We investigated the association of exposure to moderate air pollution during pregnancy, infancy, and preschool time with lung function at school age in a Swiss population-based study.
METHODS
Fine-scale spatiotemporal model estimates of particulate matter with a diameter <2.5 µm (PM2.5) and nitrogen dioxide (NO2) were linked with residential address histories. We compared air pollution exposures within different time windows (whole pregnancy, first, second, and third trimester of pregnancy, first year of life, preschool age) with forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) measured cross-sectionally using linear regression models adjusted for potential confounders.
RESULTS
We included 2182 children, ages 6-17 years. Prenatal air pollution exposure was associated with reduced lung function at school age. In children aged 12 years, per 10 µg·m-3 increase in PM2.5 during pregnancy, FEV1 was 55 mL lower (95% CI -84 to -25 mL) and FVC 62 mL lower (95% CI -96 to -28 mL). Associations were age-dependent since they were stronger in younger and weaker in older children. PM2.5 exposure after birth was not associated with reduced lung function. There was no association between NO2 exposure and lung function.
CONCLUSION
In utero lung development is most sensitive to air pollution exposure, since even modest PM2.5 exposure during the prenatal time was associated with reduced lung function, most prominent in younger children.
Actions (login required)
 |
Edit item |