Beierle, John M; Horne, W Seth; van Maarseveen, Jan H; Waser, Beatrice; Reubi, Jean-Claude; Ghadiri, M Reza (2009). Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: receptor-selective somatostatin analogues. Angewandte Chemie (International ed.), 48(26), pp. 4725-9. Weinheim: Wiley-VCH 10.1002/anie.200805901
Full text not available from this repository. (Request a copy)A would-be amide: A 1,4-disubstituted 1,2,3-triazole was used as a surrogate for a trans amide bond to create a library of 16 diastereomeric pseudotetrapeptides as beta-turn mimetics. High-resolution structural analysis indicated that these scaffolds adopt distinct, rigid, conformationally homogeneous beta-turn-like structures (see example), some of which bind somatostatin receptor subtypes selectively, and some of which show broad-spectrum activity.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Waser, Beatrice, Reubi-Kattenbusch, Jean-Claude |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1433-7851 |
ISBN: |
19266506 |
Publisher: |
Wiley-VCH |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:08 |
Last Modified: |
05 Dec 2022 14:21 |
Publisher DOI: |
10.1002/anie.200805901 |
PubMed ID: |
19266506 |
Web of Science ID: |
000267494500006 |
URI: |
https://boris.unibe.ch/id/eprint/29976 (FactScience: 165567) |
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