High-density electrode array for imaging in vitro electrophysiological activity

Berdondini, L; van der Wal, P D; Guenat, O; de Rooij, N F; Koudelka-Hep, M; Seitz, P; Kaufmann, R; Metzler, P; Blanc, N; Rohr, S (2005). High-density electrode array for imaging in vitro electrophysiological activity. Biosensors & bioelectronics, 21(1), pp. 167-74. Barking, UK: Elsevier 10.1016/j.bios.2004.08.011

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The development of a high-density active microelectrode array for in vitro electrophysiology is reported. Based on the Active Pixel Sensor (APS) concept, the array integrates 4096 gold microelectrodes (electrode separation 20 microm) on a surface of 2.5 mmx2.5 mm as well as a high-speed random addressing logic allowing the sequential selection of the measuring pixels. Following the electrical characterization in a phosphate solution, the functional evaluation has been carried out by recording the spontaneous electrical activity of neonatal rat cardiomyocytes. Signals with amplitudes from 130 microVp-p to 300 microVp-p could be recorded from different pixels. The results demonstrate the suitability of the APS concept for developing a new generation of high-resolution extracellular recording devices for in vitro electrophysiology.

Item Type:	Journal Article (Original Article)
Division/Institute:	10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Organs-on Chip Technologies
UniBE Contributor:	Guenat, Olivier Thierry
ISSN:	0956-5663
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:24
Last Modified:	05 Dec 2022 14:26
Publisher DOI:	10.1016/j.bios.2004.08.011
PubMed ID:	15967365
Web of Science ID:	000232268900020
URI:	https://boris.unibe.ch/id/eprint/37892 (FactScience: 212178)