Berdondini, L; van der Wal, P D; Guenat, O; de Rooij, N F; Koudelka-Hep, M; Seitz, P; Kaufmann, R; Metzler, P; Blanc, N; Rohr, S (2005). High-density electrode array for imaging in vitro electrophysiological activity. Biosensors & bioelectronics, 21(1), pp. 167-74. Barking, UK: Elsevier 10.1016/j.bios.2004.08.011
Full text not available from this repository. (Request a copy)The development of a high-density active microelectrode array for in vitro electrophysiology is reported. Based on the Active Pixel Sensor (APS) concept, the array integrates 4096 gold microelectrodes (electrode separation 20 microm) on a surface of 2.5 mmx2.5 mm as well as a high-speed random addressing logic allowing the sequential selection of the measuring pixels. Following the electrical characterization in a phosphate solution, the functional evaluation has been carried out by recording the spontaneous electrical activity of neonatal rat cardiomyocytes. Signals with amplitudes from 130 microVp-p to 300 microVp-p could be recorded from different pixels. The results demonstrate the suitability of the APS concept for developing a new generation of high-resolution extracellular recording devices for in vitro electrophysiology.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Organs-on Chip Technologies |
UniBE Contributor: |
Guenat, Olivier Thierry |
ISSN: |
0956-5663 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:24 |
Last Modified: |
05 Dec 2022 14:26 |
Publisher DOI: |
10.1016/j.bios.2004.08.011 |
PubMed ID: |
15967365 |
Web of Science ID: |
000232268900020 |
URI: |
https://boris.unibe.ch/id/eprint/37892 (FactScience: 212178) |
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