Krzystanek, Katarzyna; Rasmussen, Hanne Borger; Grunnet, Morten; Staub, Olivier; Olesen, Søren-Peter; Abriel, Hugues; Jespersen, Thomas (2012). Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. Heart, 9(3), pp. 440-8. London: BMJ Publishing Group 10.1016/j.hrthm.2011.10.026
Full text not available from this repository.KCNQ1 (Kv7.1), together with its KCNE β subunits, plays a pivotal role both in the repolarization of cardiac tissue and in water and salt transport across epithelial membranes. Nedd4/Nedd4-like (neuronal precursor cell-expressed developmentally downregulated 4) ubiquitin-protein ligases interact with the KCNQ1 potassium channel through a PY motif located in the C terminus of KCNQ1. This interaction induces ubiquitylation of KCNQ1, resulting in a reduced surface density of the channel. It was reported recently that the epithelial sodium channel is regulated by the reverse process-deubiquitylation-mediated by USP2 (ubiquitin-specific protease 2).
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten |
UniBE Contributor: |
Abriel, Hugues |
ISSN: |
1355-6037 |
Publisher: |
BMJ Publishing Group |
Funders: |
[4] Swiss National Science Foundation |
Projects: |
[12] In vivo relevance of the PY and PDZ-domain binding motifs of the cardiac sodium channel Nav1.5 Official URL |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:20 |
Last Modified: |
05 Dec 2022 14:05 |
Publisher DOI: |
10.1016/j.hrthm.2011.10.026 |
PubMed ID: |
22024150 |
Web of Science ID: |
000300712700028 |
URI: |
https://boris.unibe.ch/id/eprint/6853 (FactScience: 211892) |
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