Influence of muscle fiber orientation on water and metabolite relaxation times, magnetization transfer, and visibility in human skeletal muscle

Macmillan, Erin; Bolliger, Christine; Boesch, Christoph Hans; Kreis, Roland (2015). Influence of muscle fiber orientation on water and metabolite relaxation times, magnetization transfer, and visibility in human skeletal muscle. Magnetic resonance in medicine, 75(4), pp. 1764-1770. Wiley-Liss 10.1002/mrm.25778

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PURPOSE

To gain a deeper understanding of the influence of skeletal muscle fiber orientation on metabolite visibility, magnetization transfer from water, and water proton relaxation rates in (1) H MR spectra.

METHODS

Non-water-suppressed MR spectroscopy was performed in tibialis anterior muscle (TA) of 10 healthy adults, with the TA oriented either parallel or at the magic angle to the 3T field. Spectra were acquired with metabolite-cycled PRESS, and water inversion from 50 to 2510 ms before excitation. Water proton T2 relaxation was sampled with STEAM with echo times from 12 to 272 ms.

RESULTS

Apparent concentrations of total creatine (tCr), taurine, and trimethylammonium compounds were reduced by 29% to 67% when TA was parallel to B0 . Both tCr peak areas were strongly correlated to the methylene peak splitting. Magnetization transfer rates from water to tCr CH3 were not significantly different between orientations. Water T1 s were similar between orientations, but T2 s were statistically significantly shorter by 1 ms in the parallel orientation (P = 0.002).

CONCLUSION

Muscle metabolite visibilities in MR spectroscopy and water T2 times depend substantially on muscle fiber orientation relative to B0 . In contrast, magnetization transfer rates appear to depend on muscle composition, rather than fiber orientation. Magn Reson Med, 2015. © 2015 Wiley Periodicals, Inc.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Abt. Magnetresonanz-Spektroskopie und Methodologie, AMSM

Graduate School:

 Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

 Macmillan, Erin, Bolliger, Christine, Boesch, Christoph Hans, Kreis, Roland

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 0740-3194

Publisher:

 Wiley-Liss

Language:

 English

Submitter:

 Christoph Hans Boesch

Date Deposited:

 30 Jun 2015 08:00

Last Modified:

 05 Dec 2022 14:48

Publisher DOI:

 10.1002/mrm.25778

PubMed ID:

 25982125

Additional Information:

E.MacMillan and C.Bollinger have been PhD students in the same department as the other authors (DIPR Magnetresonanz-Spektroskopie und Methodologie (AMSM) until 2013

Uncontrolled Keywords:

 proton MR spectroscopy; muscle; orientation; magnetization transfer; magic angle

BORIS DOI:

 10.7892/boris.69840

URI:

 https://boris.unibe.ch/id/eprint/69840

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