Diversity, virulence, and antimicrobial resistance of the KPC-producing Klebsiella pneumoniae ST307 clone

Villa, Laura; Feudi, Claudia; Fortini, Daniela; Brisse, Sylvain; Passet, Virginie; Bonura, Celestino; Endimiani, Andrea; Mammina, Caterina; Ocampo, Ana Maria; Jimenez, Judy Natalia; Doumith, Michel; Woodford, Neil; Hopkins, Katie; Carattoli, Alessandra (2017). Diversity, virulence, and antimicrobial resistance of the KPC-producing Klebsiella pneumoniae ST307 clone. Microbial genomics, 3(4) Microbiology Society 10.1099/mgen.0.000110

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The global spread of KPC carbapenemase-producing Klebsiella pneumoniae has been mainly associated with the dissemination of high-risk clones. Most of the hospital outbreaks reported in the last decade have been attributed to isolates belonging to Clonal Group 258. However, recent epidemiological analysis suggests that a new clone, sequence type (ST) 307, is emerging in different parts of the world and is a candidate to become one of the most prevalent high-risk clones in the near future. Here we show that the ST307 genome encodes features that can provide an advantage in adaptation in the hospital environment and in the human host. These include novel plasmid-located virulence clusters, such as a cluster for glycogen synthesis. Glycogen production is considered one of the possible adaptive responses to long-term survival and growth in environments outside the host. Chromosomally-encoded virulence traits, including fimbriae, an Integrative Conjugative Element carrying the yersiniabactin siderophore, and two different capsular loci were identified. Resistance to complement was verified in capsulated and uncapsulated ST307 strains. The acquired genetic features identified in the genome of this new emerging clone may contribute to increased persistence of ST307 in the hospital environment, and shed light on its potential epidemiological success.

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