Charles, Roch-Philippe

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2018

Häfliger, Pascal; Graff, Julien; Rubin, Matthias; Stooss, Amandine; Dettmer, Matthias S.; Altmann, Karl-Heinz; Gertsch, Jürg; Charles, Roch-Philippe (2018). The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model. Journal of experimental & clinical cancer research, 37(1), p. 234. BioMed Central 10.1186/s13046-018-0907-z

2017

Rölli, Matthias Andreas; Ruffieux-Daidiée, Dorothée; Stooss, Amandine; El Mokh, Oussama; Phillips, Wayne A; Dettmer, Matthias; Charles, Roch-Philippe (2017). PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors. OncoTarget, 8(61), pp. 103207-103222. Impact Journals LLC 10.18632/oncotarget.21732

Chicca, Andrea; Nicolussi, Simon; Bartholomäus, Ruben; Blunder, Martina; Aparisi Rey, Alejandro; Petrucci, Vanessa; Reynoso, Ines del Carmen; Viveros-Paredes, Juan Manuel; Dalghi Gens, Marianela Gisela; Lutz, Beat; Schiöth, Helgi B; Soeberdt, Michael; Abels, Christoph; Charles, Roch-Philippe; Altmann, Karl-Heinz; Gertsch, Jürg (2017). Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 114(25), E5006-E5015. National Academy of Sciences NAS 10.1073/pnas.1704065114

Nisa Hernández, Lluís; Häfliger, Pascal; Poliakova, Michaela; Giger, Roland; Francica, Paola; Aebersold, Daniel; Charles, Roch-Philippe; Zimmer, Yitzhak; Medova, Michaela (2017). PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models. Molecular cancer, 16(1), p. 93. BioMed Central 10.1186/s12943-017-0660-5

El Mokh, Oussama; Ruffieux-Daidié, Dorothée; Rölli, Matthias Andreas; Stooss, Amandine; Phillips, Wayne A; Gertsch, Jürg; Dettmer, Matthias; Charles, Roch-Philippe (2017). Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo. OncoTarget, 8(15), pp. 24604-24620. Impact Journals LLC 10.18632/oncotarget.15599

Kind, Marcus Johann; Klukowska-Rötzler, Jolanta; Berezowska, Sabina Anna; Arcaro, Alexandre; Charles, Roch-Philippe (2017). Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis. PLoS ONE, 12(10), e0187308. Public Library of Science 10.1371/journal.pone.0187308

2015

Simonin, Céline; Awale, Mahendra; Brand, Michael; van Deursen, Ruud; Schwartz, Julian; Fine, Michael; Kovacs, Gergely; Häfliger, Pascal; Gyimesi, Gergely; Sithampari, Abilashan; Charles, Roch-Philippe; Hediger, Matthias; Reymond, Jean-Louis (2015). Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method. Angewandte Chemie (International ed.), 54(49), pp. 14748-14752. Wiley-VCH 10.1002/anie.201507320

Chicca, Andrea; Gachet Otanez, Maria Salomé; Petrucci, Vanessa; Schuehly, Wolfgang; Charles, Roch-Philippe; Gertsch, Jürg (2015). 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. Journal of neuroinflammation, 12, p. 89. BioMed Central 10.1186/s12974-015-0307-7

Charles, Roch-Philippe (2015). Overview of Genetically Engineered Mouse Models of Papillary and Anaplastic Thyroid Cancers: Enabling Translational Biology for Patient Care Improvement. Current protocols in pharmacology, 69, 14.33.1-14.3314. Wiley 10.1002/0471141755.ph1433s69

2014

Malsure, Sumedha; Wang, Qing; Charles, Roch-Philippe; Sergi, Chloe; Perrier, Romain; Christensen, Birgitte Mønster; Maillard, Marc; Rossier, Bernard C; Hummler, Edith (2014). Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistance. Journal of the American Society of Nephrology, 25(7), pp. 1453-1464. Lippincott Williams & Wilkins 10.1681/ASN.2013090936

Charles, Roch-Philippe; Silva, Jillian; Iezza, Gioia; Phillips, Wayne A; McMahon, Martin (2014). Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis. Molecular cancer research, 12(7), pp. 979-986. American Association for Cancer Research AACR 10.1158/1541-7786.MCR-14-0158-T

2013

Yang, Hsin-Ya; Charles, Roch-Philippe; Hummler, Edith; Baines, Deborah L.; Isseroff, R. Rivkah (2013). The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes. Journal of cell science, 126(Pt 9), pp. 1942-1951. Company of Biologists Limited 10.1242/jcs.113225

Hummler, Edith; Dousse, Aline; Rieder, Audrey; Stehle, Jean-Christophe; Rubera, Isabelle; Osterheld, Maria-Chiara; Beermann, Friedrich; Frateschi, Simona; Charles, Roch-Philippe (2013). The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation. PLoS ONE, 8(2), e55796. Public Library of Science 10.1371/journal.pone.0055796

Charles, Roch-Philippe; Silva, Jilian; Iezza, Gioia; Phillips, Wayne A; McMahon, Martin (2013). BRAF V600E and PIK3CA H1074R cooperate to promote progression of anaplastic thyroid carcinoma in the mouse. Endocrine abstracts, 32(S16.1) BioScientifica 10.1530/endoabs.32.s16.1

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