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Beyoğlu, Diren; Huang, Pinzhu; Skelton-Badlani, Disha; Zong, Christine; Popov, Yury V; Idle, Jeffrey R (2023). Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis. Cells, 12(3) MDPI 10.3390/cells12030485
Beyoğlu, Diren; Schwalm, Stephanie; Semmo, Nasser; Huwiler, Andrea; Idle, Jeffrey R (2023). Hepatitis C Virus Infection Upregulates Plasma Phosphosphingolipids and Endocannabinoids and Downregulates Lysophosphoinositols. International journal of molecular sciences, 24(2) MDPI 10.3390/ijms24021407
Simillion, Cedric; Semmo, Nasser; Idle, Jeffrey; Beyoglu, Diren (2017). Robust Regression Analysis of GCMS Data Reveals Differential Rewiring of Metabolic Networks in Hepatitis B and C Patients. Metabolites, 7(4) MDPI 10.3390/metabo7040051
Keogh, Adrian; Şenkardeş, Sevil; Idle, Jeffrey; Küçükgüzel, Ş Güniz; Beyoglu, Diren (2017). A Novel Anti-Hepatitis C Virus and Antiproliferative Agent Alters Metabolic Networks in HepG2 and Hep3B Cells. Metabolites, 7(2) MDPI 10.3390/metabo7020023
Pabst, Thomas; Kortz, Linda; Fiedler, Georg Martin; Ceglarek, Uta; Idle, Jeffrey; Beyoglu, Diren (2017). The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features. BBA clinical, 7, pp. 105-114. Elsevier 10.1016/j.bbacli.2017.03.002
Golla, Srujana; Golla, Jaya Prakash; Krausz, Kristopher W; Manna, Soumen K; Simillion, Cedric; Beyoglu, Diren; Idle, Jeffrey; Gonzalez, Frank J (2017). Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure. Radiation research, 187(5), pp. 612-629. Radiation Research Society 10.1667/RR14592.1
Patel, Daxesh P; Krausz, Kristopher W; Xie, Cen; Beyoglu, Diren; Gonzalez, Frank J; Idle, Jeffrey (2017). Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice. PLoS ONE, 12(5), e0177953. Public Library of Science 10.1371/journal.pone.0177953
Wang, Min; Keogh, Adrian; Treves, Susan; Idle, Jeffrey; Beyoglu, Diren (2016). The metabolomic profile of gamma-irradiated human hepatoma and muscle cells reveals metabolic changes consistent with the Warburg effect. PeerJ, 4, e1624. PeerJ, Ltd 10.7717/peerj.1624
Beyoglu, Diren; Krausz, K. W.; Martin, Juliette; Maurhofer, Olivier; Dorow, J.; Ceglarek, U.; Gonzalez, F. J.; Dufour, Jean-François; Idle, Jeffrey (2014). Disruption of tumor suppressor gene Hint1 leads to remodeling of the lipid metabolic phenotype of mouse liver. Journal of lipid research, 55(11), pp. 2309-2319. American Society for Biochemistry and Molecular Biology ASBMB 10.1194/jlr.M050682
Wang, Haina; Fang, Zhong-Ze; Zheng, Yang; Zhou, Kun; Hu, Changyan; Krausz, Kristopher W.; Sun, Dequn; Idle, Jeffrey; Gonzalez, Frank J. (2014). Metabolic profiling of praziquantel enantiomers. Biochemical pharmacology, 90(2), pp. 166-178. Elsevier 10.1016/j.bcp.2014.05.001
Mathe, E. A.; Patterson, A. D.; Haznadar, M.; Manna, S. K.; Krausz, K. W.; Bowman, E. D.; Shields, P. G.; Idle, Jeffrey; Smith, P. B.; Anami, K.; Kazandjian, D. G.; Hatzakis, E.; Gonzalez, F. J.; Harris, C. C. (2014). Noninvasive Urinary Metabolomic Profiling Identifies Diagnostic and Prognostic Markers in Lung Cancer. Cancer research, 74(12), pp. 3259-3270. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-14-0109
Beyoglu, Diren; Idle, Jeffrey (2014). Painting the liver with lasers: The future of liver histology? Hepatology, 59(3), pp. 757-760. Wiley Interscience 10.1002/hep.26734
Semmo, Nasser; Semmo, Nasser; Weber, Thomas; Idle, Jeffrey; Idle, Jeffrey; Beyoglu, Diren (2014). Metabolomics reveals that aldose reductase activity due to AKR1B10 is upregulated in hepatitis C virus infection. Journal of viral hepatitis, 22(7), pp. 617-624. Blackwell Science 10.1111/jvh.12376
Cheng, Jie; Zhen, Yueying; Miksys, Sharon; Beyoglu, Diren; Krausz, Kristopher W.; Tyndale, Rachel F.; Yu, Aiming; Idle, Jeffrey R.; Gonzalez, Frank J. (2013). Potential role of CYP2D6 in the central nervous system. Xenobiotica, 43(11), pp. 973-984. Informa Healthcare 10.3109/00498254.2013.791410
Fang, Zhong-Ze; Krausz, Kristopher W.; Tanaka, Naoki; Li, Fei; Qu, Aijuan; Idle, Jeffrey R.; Gonzalez, Frank J. (2013). Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum. Archives of toxicology, 87(11), pp. 1975-1987. Springer 10.1007/s00204-013-1053-1
Beyoglu, Diren; Imbeaud, Sandrine; Maurhofer, Olivier; Bioulac-Sage, Paulette; Zucman-Rossi, Jessica; Dufour, Jean-François; Idle, Jeffrey R. (2013). Tissue metabolomics of hepatocellular carcinoma: Tumor energy metabolism and the role of transcriptomic classification. Hepatology, 58(1), pp. 229-238. Wiley Interscience 10.1002/hep.26350
Manna, Soumen K.; Krausz, Kristopher W.; Bonzo, Jessica A.; Idle, Jeffrey; Gonzalez, Frank J. (2013). Metabolomics Reveals Aging-associated Attenuation of Noninvasive Radiation Biomarkers in Mice: Potential Role of Polyamine Catabolism and Incoherent DNA Damage-repair. Journal of proteome research, 12(5), pp. 2269-2281. American Chemical Society 10.1021/pr400161k
Johnson, Caroline H.; Bonzo, Jessica A.; Cheng, Jie; Krausz, Kristopher W.; Kang, Dong W.; Luecke, Hans; Idle, Jeffrey R.; Gonzalez, Frank J. (2013). Cytochrome P450 Regulation by -Tocopherol in Pxr-Null and PXR-Humanized Mice. Drug metabolism and disposition, 41(2), pp. 406-413. American Society for Pharmacology and Experimental Therapeutics 10.1124/dmd.112.048009
Cheng, Jie; Chen, Chi; Kristopher, Krausz W.; Manna, Soumen K.; Scerba, Mike; Friedman, Fred K.; Luecke, Hans; Idle, Jeffrey R.; Gonzalez, Frank J. (2013). Identification of 2-Piperidone as a Biomarker of CYP2E1 Activity Through Metabolomic Phenotyping. Toxicological sciences, 135(1), pp. 37-47. Oxford University Press 10.1093/toxsci/kft143
Beyoglu, Diren; Idle, Jeffrey (2013). The metabolomic window into hepatobiliary disease. Journal of hepatology, 59(4), pp. 842-858. Elsevier 10.1016/j.jhep.2013.05.030
Beyoglu, Diren; Idle, Jeffrey (2013). Metabolomics and its potential in drug development. Biochemical pharmacology, 85(1), pp. 12-20. Elsevier 10.1016/j.bcp.2012.08.013
Johnson, Caroline H; Patterson, Andrew D; Krausz, Kristopher W; Kalinich, John F; Tyburski, John B; Kang, Dong Wook; Luecke, Hans; Gonzalez, Frank J; Blakely, William F; Idle, Jeffrey R (2012). Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics. Radiation research, 178(4), pp. 328-40. Lawrence, Kans.: Radiation Research Society 10.1667/RR2950.1
Johnson, Caroline H; Slanař, Ondřej; Krausz, Kristopher W; Kang, Dong Wook; Patterson, Andrew D; Kim, Jung-Hwan; Luecke, Hans; Gonzalez, Frank J; Idle, Jeffrey R (2012). Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics. American journal of clinical nutrition, 96(4), pp. 818-30. Bethesda, Md.: American Society for Nutrition, Inc. 10.3945/ajcn.112.042929
Beyoğlu, Diren; Idle, Jeffrey R (2012). The glycine deportation system and its pharmacological consequences. Pharmacology & therapeutics, 135(2), pp. 151-67. Amsterdam: Elsevier 10.1016/j.pharmthera.2012.05.003
Li, Fei; Patterson, Andrew D; Krausz, Kristopher W; Dick, Bernhard; Frey, Felix J; Gonzalez, Frank J; Idle, Jeffrey R (2012). Metabolomics reveals the metabolic map of procainamide in humans and mice. Biochemical pharmacology, 83(10), pp. 1435-44. New York, N.Y.: Elsevier 10.1016/j.bcp.2012.02.013
Beyoğlu, Diren; Smith, Robert L; Idle, Jeffrey R (2012). Dog bites man or man bites dog? The enigma of the amino acid conjugations. Biochemical pharmacology, 83(10), pp. 1331-9. New York, N.Y.: Elsevier 10.1016/j.bcp.2011.12.031
Johnson, Caroline H; Patterson, Andrew D; Idle, Jeffrey R; Gonzalez, Frank J (2012). Xenobiotic metabolomics: major impact on the metabolome. Annual review of pharmacology and toxicology, 52, pp. 37-56. Palo Alto, Calif.: Annual Reviews Inc. 10.1146/annurev-pharmtox-010611-134748
Fahrner, René; Beyoğlu, Diren; Beldi, Guido; Idle, Jeffrey R (2012). Metabolomic markers for intestinal ischemia in a mouse model. Journal of surgical research, 178(2), pp. 879-87. New York, N.Y.: Elsevier 10.1016/j.jss.2012.08.011
Patterson, Andrew D; Maurhofer, Olivier; Beyoglu, Diren; Lanz, Christian; Krausz, Kristopher W; Pabst, Thomas; Gonzalez, Frank J; Dufour, Jean-François; Idle, Jeffrey R (2011). Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling. Cancer research, 71(21), pp. 6590-600. Birmingham, Ala.: American Association for Cancer Research AACR 10.1158/0008-5472.CAN-11-0885
Manna, Soumen K; Patterson, Andrew D; Yang, Qian; Krausz, Kristopher W; Idle, Jeffrey R; Fornace, Albert J; Gonzalez, Frank J (2011). UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. Journal of proteome research, 10(9), pp. 4120-33. Washington, D.C.: American Chemical Society 10.1021/pr200310s
Hague, David E; Idle, Jeffrey R; Mitchell, Steve C; Smith, Robert L (2011). Racemates revisited: heterochiral assemblies and the example of DL-thalidomide. Xenobiotica, 41(10), pp. 837-43. London: Informa Healthcare 10.3109/00498254.2011.590547
Patterson, Andrew D; Bonzo, Jessica A; Li, Fei; Krausz, Kristopher W; Eichler, Gabriel S; Aslam, Sadaf; Tigno, Xenia; Weinstein, John N; Hansen, Barbara C; Idle, Jeffrey R; Gonzalez, Frank J (2011). Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. Journal of biological chemistry, 286(22), pp. 19511-22. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M111.221739
Johnson, Caroline H; Patterson, Andrew D; Krausz, Kristopher W; Lanz, Christian; Kang, Dong Wook; Luecke, Hans; Gonzalez, Frank J; Idle, Jeffrey R (2011). Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats. Radiation research, 175(4), pp. 473-84. Lawrence, Kans.: Radiation Research Society 10.1667/RR2437.1
Li, Fei; Patterson, Andrew D; Höfer, Constance C; Krausz, Kristopher W; Gonzalez, Frank J; Idle, Jeffrey R (2011). A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochemical pharmacology, 81(8), pp. 1043-53. New York, N.Y.: Elsevier 10.1016/j.bcp.2011.01.024
Lanz, Christian; Ledermann, Monika; Slavík, Josef; Idle, Jeffrey R (2011). The production and composition of rat sebum is unaffected by 3 Gy gamma radiation. International journal of radiation biology, 87(4), pp. 360-71. London: Taylor & Francis 10.3109/09553002.2010.537432
Gonzalez, F; Patterson, A; Krausz, K; Idle, J (2011). Investigating the roles of lipids in disease and chemical toxicities using metabolomics. Chemistry and physics of lipids, 164, S5. Shannon: Elsevier Scientific Publishers 10.1016/j.chemphyslip.2011.05.041
Wang, Ting; Shah, Yatrik M; Matsubara, Tsutomu; Zhen, Yueying; Tanabe, Tomotaka; Nagano, Tomokazu; Fotso, Serge; Krausz, Kristopher W; Zabriskie, T Mark; Idle, Jeffrey; Gonzalez, Frank J (2010). Control of Steroid 21-oic Acid Synthesis by Peroxisome Proliferator-activated Receptor and Role of the Hypothalamic-Pituitary-Adrenal Axis. Journal of biological chemistry, 285(10), pp. 7670-7685. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M109.090175
Cho, Joo-Youn; Matsubara, Matsubara; Kang, Dong Wook; Ahn, Sung-Hoon; Krausz, Kirstopher W; Idle, Jeffrey; Luecke, Hans; Gonzalez, Frank J (2010). Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge. Journal of lipid research, 51(5), pp. 1063-1074. Bethesda, Md.: American Society for Biochemistry and Molecular Biology ASBMB 10.1194/jlr.M002923
Niu, Sida; Li, Feng; Tan, Dun-Xian; Zhang, Lirong; Idle, Jeffrey R; Gonzalez, Frank J; Ma, Xiaochao (2010). Analysis of N1-acetyl-N2-formyl-5-methoxykynuramine/N1-acetyl-5-methoxy-kynuramine formation from melatonin in mice. Journal of pineal research, 49(2), pp. 106-14. Oxford: Wiley-Blackwell 10.1111/j.1600-079X.2010.00771.x
Li, Fei; Patterson, Andrew D; Höfer, Constance C; Krausz, Kristopher W; Gonzalez, Frank J; Idle, Jeffrey R (2010). Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochemical pharmacology, 80(7), pp. 1063-74. New York, N.Y.: Elsevier 10.1016/j.bcp.2010.06.002
Manna, Soumen K; Patterson, Andrew D; Yang, Qian; Krausz, Kristopher W; Li, Henghong; Idle, Jeffrey R; Fornace, Albert J; Gonzalez, Frank J (2010). Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse. Journal of proteome research, 9(8), pp. 4176-88. Washington, D.C.: American Chemical Society 10.1021/pr100452b
Patterson, Andrew D; Gonzalez, Frank J; Idle, Jeffrey R (2010). Xenobiotic metabolism: a view through the metabolometer. Chemical research in toxicology, 23(5), pp. 851-60. Washington, D.C.: American Chemical Society 10.1021/tx100020p
Patterson, Andrew D.; Lanz, Christian; Gonzalez, Frank J.; Idle, Jeffrey (2009). The role of mass spectrometry-based metabolomics in medical countermeasures against radiation. Mass Spectrometry Reviews, 29(3), pp. 503-521. New York, N.Y.: Wiley 10.1002/mas.20272
Tyburski, John B; Patterson, Andrew D; Krausz, Kristopher W; Slavík, Josef; Fornace, Albert J; Gonzalez, Frank J; Idle, Jeffrey R (2009). Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiation research, 172(1), pp. 42-57. Lawrence, Kans.: Radiation Research Society 10.1667/RR1703.1
Lanz, Christian; Patterson, Andrew D; Slavík, Josef; Krausz, Kristopher W; Ledermann, Monika; Gonzalez, Frank J; Idle, Jeffrey R (2009). Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm. Radiation research, 172(2), pp. 198-212. Lawrence, Kans.: Radiation Research Society 10.1667/RR1796.1
Chen, Chi; Krausz, Kristopher W; Shah, Yatrik M; Idle, Jeffrey R; Gonzalez, Frank J (2009). Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. Chemical research in toxicology, 22(4), pp. 699-707. Washington, D.C.: American Chemical Society 10.1021/tx800464q
Tyburski, John B; Patterson, Andrew D; Krausz, Kristopher W; Slavík, Josef; Fornace, Albert J; Gonzalez, Frank J; Idle, Jeffrey R (2008). Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice. Radiation research, 170(1), pp. 1-14. Lawrence, Kans.: Radiation Research Society 10.1667/RR1265.1
Patterson, Andrew D; Li, Henghong; Eichler, Gabriel S; Krausz, Kristopher W; Weinstein, John N; Fornace, Albert J; Gonzalez, Frank J; Idle, Jeffrey R (2008). UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Analytical chemistry, 80(3), pp. 665-74. Washington, D.C.: American Chemical Society 10.1021/ac701807
Ma, Xiaochao; Idle, Jeffrey R; Malfatti, Michael A; Krausz, Kristopher W; Nebert, Daniel W; Chen, Chong-Sheng; Felton, James S; Waxman, David J; Gonzalez, Frank J (2007). Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 28(3), pp. 732-737. Oxford: Oxford University Press 10.1093/carcin/bgl184
Lerch, Stefanie; Küpfer, Adrian; Idle, Jeffrey R; Lauterburg, Bernhard H (2006). Cerebral formation in situ of S-carboxymethylcysteine after ifosfamide administration to mice: a further clue to the mechanism of ifosfamide encephalopathy. Toxicology letters, 161(3), pp. 188-94. Amsterdam: Elsevier 10.1016/j.toxlet.2005.09.002
Herraiz, Tomás; Guillén, Hugo; Arán, Vicente J; Idle, Jeffrey R; Gonzalez, Frank J (2006). Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6. Toxicology and Applied Pharmacology, 216(3), pp. 387-98. Amsterdam: Elsevier 10.1016/j.taap.2006.06.003
Zhen, Yueying; Slanar, Ondrej; Krausz, Kristopher W; Chen, Chi; Slavík, Josef; McPhail, Kerry L; Zabriskie, T Mark; Perlík, Frantisek; Gonzalez, Frank J; Idle, Jeffrey R (2006). 3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio. Drug metabolism and disposition, 34(9), pp. 1563-74. Bethesda, Md.: American Society for Pharmacology and Experimental Therapeutics 10.1124/dmd.105.008920
Giri, Sarbani; Idle, Jeffrey R; Chen, Chi; Zabriskie, T Mark; Krausz, Kristopher W; Gonzalez, Frank J (2006). A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse. Chemical research in toxicology, 19(6), pp. 818-27. Washington, D.C.: American Chemical Society 10.1021/tx0600402
Chen, Chi; Meng, Linghua; Ma, Xiaochao; Krausz, Kristopher W; Pommier, Yves; Idle, Jeffrey R; Gonzalez, Frank J (2006). Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone). Journal of pharmacology and experimental therapeutics, 318(3), pp. 1330-42. Bethesda, Md.: American Society for Pharmacology and Experimental Therapeutics 10.1124/jpet.106.105213
Ma, Xiaochao; Idle, Jeffrey R; Krausz, Kristopher W; Tan, Dun-Xian; Ceraulo, Leopoldo; Gonzalez, Frank J (2006). Urinary metabolites and antioxidant products of exogenous melatonin in the mouse. Journal of pineal research, 40(4), pp. 343-9. Oxford: Wiley-Blackwell 10.1111/j.1600-079X.2006.00321.x
Slanar, O; Nobilis, M; Kvetina, J; Mikoviny, R; Zima, T; Idle, J R; Perlík, F (2006). Miotic action of tramadol is determined by CYP2D6 genotype. Physiological research, 56(1), pp. 129-136. Praha: Academia Scientiarum Bohemoslovaca
Slanar, Ondrej; Nobilis, Milan; Kvetina, Jaroslav; Idle, Jeffrey R; Perlík, Frantisek (2006). CYP2D6 polymorphism, tramadol pharmacokinetics and pupillary response. European journal of clinical pharmacology, 62(1), 75-6; author reply 77-8. Berlin: Springer 10.1007/s00228-005-0039-1
Beyoglu, Diren; Idle, Jeffrey (2014). A history and overview of phenotypic variability in CYP2D6 activity. In: Baumann, Pierre (ed.) CYP2D6: Genetics, Pharmacology and Clinical Relevance (pp. 8-27). London: Future Medicine 10.2217/FMEB2013.13.97
Beyoglu, Diren; Dufour, Jean-François; Idle, Jeffrey (February 2013). Lipid metabolomics in hepatocellular carcinoma (Unpublished). In: EASL Monothematic Conference. Luxembourg. Februar 2013.
Fahrner, R; Beyoglu, D; Idle, J; Beldi, G (2012). Intestinal ischemia is associated with increased serum amino acids in a mouse. In: Jahreskongress SGC Davos.
