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Boubaker, Ghalia; Bernal, Alice; Vigneswaran, Anitha; Imhof, Dennis; Ferreira de Sousa, Maria Cristina; Hänggeli, Kai Pascal Alexander; Haudenschild, Noé; Furrer, Julien; Păunescu, Emilia; Desiatkina, Oksana; Hemphill, Andrew (2024). In vitro and in vivo activities of a trithiolato-diRuthenium complex conjugated with sulfadoxine against the apicomplexan parasite Toxoplasma gondii. International journal for parasitology. Drugs and drug resistance, 25(100544), p. 100544. Elsevier 10.1016/j.ijpddr.2024.100544
Müller, Joachim; Boubaker, Ghalia; Müller, Norbert; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Hemphill, Andrew (2024). Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools-Chances and Limitations: A Critical Review. International journal of molecular sciences, 25(13) MDPI 10.3390/ijms25136903
Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Ferreira de Sousa, Maria Cristina; Vigneswaran, Anitha; Hofmann, Larissa; Amdouni, Yosra; Boubaker, Ghalia; Müller, Joachim; Hemphill, Andrew (2024). Working towards the development of vaccines and chemotherapeutics against neosporosis—With all of its ups and downs—Looking ahead. Advances in Parasitology, 124, pp. 91-154. Elsevier 10.1016/bs.apar.2024.01.001
Rico-San Román, Laura; Hänggeli, Kai Pascal Alexander; Hemphill, Andrew; Horcajo, Pilar; Collantes-Fernández, Esther; Ortega-Mora, Luis Miguel; Boubaker, Ghalia (2024). TaqMan-quantitative PCR assays applied in Neospora caninum knock-outs generated through CRISPR-Cas9 allow to determine the copy numbers of integrated dihydrofolate reductase-thymidylate synthase drug selectable markers. Frontiers in cellular and infection microbiology, 14(1419209) Frontiers 10.3389/fcimb.2024.1419209
Schlange, Carling; Müller, Joachim; Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Boubaker, Ghalia; Ortega-Mora, Luis-Miguel; Wong, Ho Ning; Haynes, Richard K; Van Voorhis, Wesley C; Hemphill, Andrew (2023). Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice. Experimental parasitology, 255(108655), p. 108655. Elsevier 10.1016/j.exppara.2023.108655
Hänggeli, Kai Pascal Alexander; Hemphill, Andrew; Müller, Norbert; Heller, Manfred; Uldry, Anne-Christine; Braga-Lagache, Sophie; Müller, Joachim; Boubaker, Ghalia (2023). Comparative Proteomic Analysis of Toxoplasma gondii RH Wild-Type and Four SRS29B (SAG1) Knock-Out Clones Reveals Significant Differences between Individual Strains. International journal of molecular sciences, 24(13) MDPI 10.3390/ijms241310454
Ramseier, Jessica; Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Anghel, Nicoleta; Boubaker, Ghalia; Beteck, Richard M; Ortega-Mora, Luis-Miguel; Haynes, Richard K; Hemphill, Andrew (2023). In Vitro versus in Mice: Efficacy and Safety of Decoquinate and Quinoline-O-Carbamate Derivatives against Experimental Infection with Neospora caninum Tachyzoites. Pathogens, 12(3) MDPI AG 10.3390/pathogens12030447
Desiatkina, Oksana; Anghel, Nicoleta; Boubaker, Ghalia; Amdouni, Yosra; Hemphill, Andrew; Furrer, Julien; Păunescu, Emilia (2023). Trithiolato-bridged dinuclear ruthenium(II)-arene conjugates tethered with lipophilic units: Synthesis and Toxoplasma gondii antiparasitic activity. Journal of organometallic chemistry, 986, p. 122624. Elsevier 10.1016/j.jorganchem.2023.122624
Holzer, Isabelle; Desiatkina, Oksana; Anghel, Nicoleta; Johns, Serena K; Boubaker, Ghalia; Hemphill, Andrew; Furrer, Julien; Păunescu, Emilia (2023). Synthesis and Antiparasitic Activity of New Trithiolato-Bridged Dinuclear Ruthenium(II)-arene-carbohydrate Conjugates. Molecules, 28(2) MDPI 10.3390/molecules28020902
Desiatkina, Oksana; Boubaker, Ghalia; Anghel, Nicoleta; Amdouni, Yosra; Hemphill, Andrew; Furrer, Julien; Paunescu, Emilia (2022). Synthesis, Photophysical Properties and Biological Evaluation of New Conjugates BODIPY - Dinuclear Trithiolato-Bridged Ruthenium(II)-Arene Complexes. ChemBioChem, 23(23), e202200536. Wiley 10.1002/cbic.202200536
Müller, Joachim; Boubaker, Ghalia; Imhof, Dennis; Hänggeli, Kai; Haudenschild, Noé; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Ortega-Mora, Luis-Miguel; Hemphill, Andrew (2022). Differential Affinity Chromatography Coupled to Mass Spectrometry: A Suitable Tool to Identify Common Binding Proteins of a Broad-Range Antimicrobial Peptide Derived from Leucinostatin. Biomedicines, 10(11) MDPI 10.3390/biomedicines10112675
Hänggeli, Kai Pascal Alexander; Hemphill, Andrew; Müller, Norbert; Schimanski, Bernd; Olias, Philipp; Müller, Joachim; Boubaker, Ghalia (2022). Single- and duplex TaqMan-quantitative PCR for determining the copy numbers of integrated selection markers during site-specific mutagenesis in Toxoplasma gondii by CRISPR-Cas9. PLoS ONE, 17(9), e0271011. Public Library of Science 10.1371/journal.pone.0271011
Desiatkina, Oksana; Mösching, Martin; Anghel, Nicoleta; Boubaker, Ghalia; Amdouni, Yosra; Hemphill, Andrew; Furrer, Julien; Păunescu, Emilia (2022). New Nucleic Base-Tethered Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Compounds: Synthesis and Antiparasitic Activity. Molecules, 27(23), p. 8173. MDPI 10.3390/molecules27238173
Karpstein, Tanja; Chaudhry, Sheena; Bresson-Hadni, Solange; Hayoz, Michael; Boubaker, Ghalia; Hemphill, Andrew; Rufener, Reto; Kaethner, Marc; Schindler, Isabelle; Aebi, Yolanda; Cunha, Antonio Sa; Largiadèr, Carlo R.; Lundström Stadelmann, Britta (2021). Maca against Echinococcosis?-A Reverse Approach from Patient to In Vitro Testing. Pathogens, 10(10) MDPI AG 10.3390/pathogens10101335
Anghel, Nicoleta; Müller, Joachim; Serricchio, Mauro; Jelk, Jennifer; Bütikofer, Peter; Boubaker, Ghalia; Imhof, Dennis; Ramseier, Jessica; Desiatkina, Oksana; Paunescu, Emilia; Braga, Sophie Marie-Pierre; Heller, Manfred; Furrer, Julien; Hemphill, Andrew (2021). Cellular and Molecular Targets of Nucleotide-Tagged Trithiolato-Bridged Arene Ruthenium Complexes in the Protozoan Parasites Toxoplasma gondii and Trypanosoma brucei. International journal of molecular sciences, 22(19) MDPI 10.3390/ijms221910787
Păunescu, Emilia; Boubaker, Ghalia; Desiatkina, Oksana; Anghel, Nicoleta; Amdouni, Yosra; Hemphill, Andrew; Furrer, Julien (2021). The Quest of the Best – A SAR Study of Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Compounds Presenting Antiparasitic Properties. European journal of medicinal chemistry, 222, p. 113610. Elsevier Masson SAS 10.1016/j.ejmech.2021.113610
Desiatkina, Oksana; Johns, Serena K.; Anghel, Nicoleta; Boubaker, Ghalia; Hemphill, Andrew; Furrer, Julien; Păunescu, Emilia (2021). Synthesis and Antiparasitic Activity of New Conjugates—Organic Drugs Tethered to Trithiolato-Bridged Dinuclear Ruthenium(II)–Arene Complexes. Inorganics, 9(8), p. 59. MDPI 10.3390/inorganics9080059
Desiatkina, Oksana; Păunescu, Emilia; Mösching, Martin; Anghel, Nicoleta; Boubaker, Ghalia; Amdouni, Yosra; Hemphill, Andrew; Furrer, Julien (2020). Coumarin‐Tagged Dinuclear Trithiolato‐Bridged Ruthenium(II)⋅Arene Complexes: Photophysical Properties and Antiparasitic Activity. ChemBioChem, 21(19), pp. 2818-2835. Wiley-VCH 10.1002/cbic.202000174
Boubaker, Ghalia; Strempel, Sebastian; Hemphill, Andrew; Müller, Norbert; Wang, Junhua; Gottstein, Bruno; Spiliotis, Markus (2020). Regulation of hepatic microRNAs in response to early stage Echinococcus multilocularis egg infection in C57BL/6 mice. PLoS neglected tropical diseases, 14(5), e0007640. Public Library of Science 10.1371/journal.pntd.0007640
Studer, Valentin; Anghel, Nicoleta; Desiatkina, Oksana; Felder, Timo; Boubaker, Ghalia; Amdouni, Yosra; Ramseier, Jessica; Hungerbühler, Martin; Kempf, Christoph; Heverhagen, Johannes Thomas; Hemphill, Andrew; Ruprecht, Nico; Furrer, Julien; Păunescu, Emilia (2020). Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents. Pharmaceuticals, 13(12), p. 471. MDPI 10.3390/ph13120471
Winzer, Pablo; Imhof, Dennis; Anghel, Nicoleta; Ritler, Dominic; Müller, Joachim; Boubaker, Ghalia; Aguado-Martinez, Adriana; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; VanVoorhis, Wesley C; Hemphill, Andrew (2020). The Impact of BKI-1294 Therapy in Mice Infected With the Apicomplexan Parasite Neospora caninum and Re-infected During Pregnancy. Frontiers in veterinary science, 7, p. 587570. Frontiers Media 10.3389/fvets.2020.587570
Kochanowski, Maciej; González-Muñoz, Miguel; Gómez-Morales, María Ángeles; Gottstein, Bruno; Dąbrowska, Joanna; Różycki, Mirosław; Cencek, Tomasz; Müller, Norbert; Boubaker, Ghalia (2019). Comparative analysis of excretory-secretory antigens of Anisakis simplex, Pseudoterranova decipiens and Contracaecum osculatum regarding their applicability for specific serodiagnosis of human anisakidosis based on IgG-ELISA. Experimental parasitology, 197, pp. 9-15. Elsevier 10.1016/j.exppara.2018.12.004
Stojkovic, Marija; Adt, Hans-Micha; Rosenberger, Kerstin; Boubaker, Ghalia; Hernandez-Gonzalez, Ana; Junghanss, Thomas; Zwahlen, Marcel; Siles-Lucas, Mar (2017). Follow-up of surgically treated patients with cystic echinococcosis: can novel recombinant antigens compete with imaging? Analysis of a patient cohort. Tropical medicine and international health TM&IH, 22(5), pp. 614-621. Blackwell Science 10.1111/tmi.12859
Marinova, Irina; Spiliotis, Markus; Wang, Junhua; Muhtarov, Marin; Chaligiannis, Ilias; Sotiraki, Smaro; Rainova, Iskra; Gottstein, Bruno; Boubaker, Ghalia (2017). Molecular characterization of Echinococcus granulosus isolates from Bulgarian human cystic echinococcosis patients. Parasitology research, 116(3), pp. 1043-1054. Springer 10.1007/s00436-017-5386-1
Dezaki, Ebrahim Saedi; Yaghoubi, Mohammad Mehdi; Spiliotis, Markus; Boubaker, Ghalia; Taheri, Elham; Almani, Pooya Ghaseminejad; Tohidi, Farideh; Harandi, Majid Fasihi; Gottstein, Bruno (2016). Comparison of ex vivo harvested and in vitro cultured materials from Echinococcus granulosus by measuring expression levels of five genes putatively involved in the development and maturation of adult worms. Parasitology research, 115(11), pp. 4405-4416. Springer 10.1007/s00436-016-5228-6
Boubaker, Ghalia; Marinova, Irina; Gori, Francesca; Hizem, Amani; Müller, Norbert; Casulli, Adriano; Jerez Puebla, Luis Enrique; Babba, Hamouda; Gottstein, Bruno; Spiliotis, Markus (2016). A dual PCR-based sequencing approach for the identification and discrimination of Echinococcus and Taenia taxa. Molecular and cellular probes, 30(4), pp. 211-217. Elsevier 10.1016/j.mcp.2016.05.004
Gottstein, Bruno; Wang, Junhua; Boubaker, Ghalia; Marinova, Irina; Spiliotis, Markus; Müller, Norbert; Hemphill, Andrew (2015). Susceptibility versus resistance in alveolar echinococcosis (larval infection with Echinococcus multilocularis). Veterinary parasitology, 213(3-4), pp. 103-109. Elsevier 10.1016/j.vetpar.2015.07.029
Chaligiannis, I; Maillard, Stephane; Boubaker, Ghalia; Spiliotis, Markus; Saratsis, A; Gottstein, Bruno; Sotiraki, S (2015). Echinococcus granulosus infection dynamics in livestock of Greece. Acta tropica, 150, pp. 64-70. Elsevier 10.1016/j.actatropica.2015.06.021
Boubaker, Ghalia; Hemphill, Andrew; Huber, Cristina Olivia; Spiliotis, Markus; Babba, Hamouda; Gottstein, Bruno (2015). Prevention and Immunotherapy of Secondary Murine Alveolar Echinococcosis Employing Recombinant EmP29 Antigen. PLoS neglected tropical diseases, 9(6), e0003795. Public Library of Science 10.1371/journal.pntd.0003795
Gottstein, Bruno; Schneeberger, Marianne; Boubaker, Ghalia; Merkle, Bernadette; Huber, Cristina; Spiliotis, Markus; Müller, Norbert; Garate, Teresa; Doherr, Marcus (2014). Comparative assessment of ELISAs using recombinant saposin-like protein 2 and recombinant cathepsin L-1 from Fasciola hepatica for the serodiagnosis of human Fasciolosis. PLoS neglected tropical diseases, 8(6), e2860. Public Library of Science 10.1371/journal.pntd.0002860
Boubaker, Ghalia; Gottstein, Bruno; Hemphill, Andrew; Babba, Hamouda; Spiliotis, Markus (2014). Echinococcus P29 antigen: molecular characterization and implication on post-surgery follow-up of CE patients infected with different species of the Echinococcus granulosus complex. PLoS ONE, 9(5), e98357. Public Library of Science 10.1371/journal.pone.0098357
Hemphill, Andrew; Lundström-Stadelmann, Britta; Rufener, Reto; Spiliotis, Markus; Boubaker, Ghalia; Müller, Joachim; Müller, Norbert; Gorgas, Daniela; Gottstein, Bruno (2014). Treatment of echinococcosis: albendazole and mebendazole - what else? Parasite, 21, p. 70. Princeps Editions 10.1051/parasite/2014073
Boubaker, Ghalia; Macchiaroli, Natalia; Prada, Laura; Cucher, Marcela A; Rosenzvit, Mara C; Ziadinov, Iskender; Deplazes, Peter; Saarma, Urmas; Babba, Hamouda; Gottstein, Bruno; Spiliotis, Markus (2013). A multiplex PCR for the simultaneous detection and genotyping of the Echinococcus granulosus complex. PLoS neglected tropical diseases, 7(1), e2017. Public Library of Science 10.1371/journal.pntd.0002017
