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Eggel, Alexander; Pennington, Luke F; Jardetzky, Theodore S (2024). Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways. (In Press). Immunological reviews Wiley-Blackwell 10.1111/imr.13380
Brigger, Daniel; Guntern, Pascal; Jonsdottir, Hulda R; Pennington, Luke F; Weber, Benjamin; Taddeo, Adriano; Zimmer, Gert; Leborgne, Nathan G F; Benarafa, Charaf; Jardetzky, Theodore S; Eggel, Alexander (2023). Sex-specific differences in immune response to SARS-CoV-2 vaccination vanish with age. Allergy, 78(6), pp. 1683-1686. Wiley 10.1111/all.15652
Benito-Villalvilla, Cristina; de la Rocha-Muñoz, Andrés; López-Abente, Jacobo; Eggel, Alexander; Bottoli, Iván; Severin, Thomas; Woisetschläger, Maximilian; Palomares, Oscar (2023). Ligelizumab impairs IgE-binding to plasmacytoid dendritic cells more potently than omalizumab and restores IFN-α production and FOXP3+ Treg generation. Allergy, 78(4), pp. 1060-1072. Wiley 10.1111/all.15567
Loste, Alexia; Clément, Marc; Delbosc, Sandrine; Guedj, Kevin; Sénémaud, Jean; Gaston, Anh-Thu; Morvan, Marion; Even, Guillaume; Gautier, Grégory; Eggel, Alexander; Arock, Michel; Procopio, Emanuele; Deschildre, Catherine; Louedec, Liliane; Michel, Jean-Baptiste; Deschamps, Lydia; Castier, Yves; Coscas, Raphaël; Alsac, Jean-Marc; Launay, Pierre; ... (2023). Involvement of an IgE/Mast cell/B cell amplification loop in abdominal aortic aneurysm progression. PLoS ONE, 18(12), e0295408. Public Library of Science 10.1371/journal.pone.0295408
Ardicli, Ozge; Carli, K Tayfun; Satitsuksanoa, Pattraporn; Dreher, Anita; Cusini, Alexia; Hutter, Sandra; Mirer, David; Rückert, Beate; Jonsdottir, Hulda R; Weber, Benjamin; Cervia, Carlo; Akdis, Mubeccel; Boyman, Onur; Eggel, Alexander; Brüggen, Marie-Charlotte; Akdis, Cezmi A; van de Veen, Willem (2022). Exposure to avian coronavirus vaccines is associated with increased levels of SARS-CoV-2-cross-reactive antibodies. Allergy, 77(12), pp. 3648-3662. Wiley-Blackwell 10.1111/all.15441
Wood, Robert A; Chinthrajah, R Sharon; Eggel, Alexander; Bottoli, Ivan; Gautier, Aurelie; Woisetschlaeger, Maximilian; Tassinari, Paolo; Altman, Pablo (2022). The rationale for development of ligelizumab in food allergy. The World Allergy Organization journal, 15(9), p. 100690. Elsevier 10.1016/j.waojou.2022.100690
Horn, Michael P; Jonsdottir, Hulda R; Brigger, Daniel; Damonti, Lauro; Suter-Riniker, Franziska; Endrich, Olga; Froehlich, Tanja K; Fiedler, Martin; Largiadèr, Carlo R; Marschall, Jonas; Weber, Benjamin; Eggel, Alexander; Nagler, Michael (2022). Serological testing for SARS-CoV-2 antibodies in clinical practice: a comparative diagnostic accuracy study. Allergy, 77(7), pp. 2090-2103. Wiley 10.1111/all.15206
Zbären, Noemi; Brigger, Daniel; Bachmann, Daniel; Helbling, Arthur; Jörg, Lukas; Horn, Michael; Schmid, Johannes M; Hoffmann, Hans Jürgen; Kinet, Jean-Pierre; Kaufmann, Thomas; Eggel, Alexander (2022). A novel functional mast cell assay for the detection of allergies. The Journal of allergy and clinical immunology, 149(3), 1018-1030.e11. Elsevier 10.1016/j.jaci.2021.08.006
Pennington, Luke F; Gasser, Pascal; Kleinboelting, Silke; Zhang, Chensong; Skiniotis, Georgios; Eggel, Alexander; Jardetzky, Theodore S (2021). Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nature Communications, 12(1), p. 7069. Springer Nature 10.1038/s41467-021-27397-z
Pennington, Luke F; Gasser, Pascal; Brigger, Daniel; Guntern, Pascal; Eggel, Alexander; Jardetzky, Theodore S (2021). Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions. Journal of allergy and clinical immunology, 148(4), pp. 1049-1060. Elsevier 10.1016/j.jaci.2021.03.050
Engeroff, Paul; Plattner, Kevin; Storni, Federico; Storni, Federico; Thoms, Franziska; Frias Boligan, Kayluz; Mürner, Lukas; Eggel, Alexander; von Gunten, Stephan; Bachmann, Martin F.; Vogel, Monique (2021). Glycan-specific IgG anti-IgE autoantibodies are protective against allergic anaphylaxis in a murine model. Journal of allergy and clinical immunology, 147(4), pp. 1430-1441. Elsevier 10.1016/j.jaci.2020.11.031
Brigger, Daniel; Riether, Carsten; van Brummelen, Robin; Mosher, Kira I; Shiu, Alicia; Ding, Zhaoqing; Zbären, Noemi; Gasser, Pascal; Guntern, Pascal; Yousef, Hanadie; Castellano, Joseph M; Storni, Federico; Graff-Radford, Neill; Britschgi, Markus; Grandgirard, Denis; Hinterbrandner, Magdalena; Siegrist, Mark; Moullan, Norman; Hofstetter, Wilhelm; Leib, Stephen L.; ... (2020). Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nature metabolism, 2(8), pp. 688-702. Springer Nature 10.1038/s42255-020-0228-3
Guntern, Pascal Martin; Eggel, Alexander (2020). Past, present, and future of anti-IgE biologics. Allergy, 75(10), pp. 2491-2502. Wiley 10.1111/all.14308
Delgado, Sharon Jiménez; Dehmel, Susann; Twisterling, Elaine; Wichmann, Judy; Jonigk, Danny; Warnecke, Gregor; Braubach, Peter; Fieguth, Hans-Gerd; Wilkens, Ludwig; Dahlmann, Franziska; Kaup, Franz-Josef; Eggel, Alexander; Knauf, Sascha; Sewald, Katherina; Braun, Armin (2020). Disruptive anti-IgE inhibitors prevent mast cell-dependent early airway response in viable atopic lung tissue. Journal of allergy and clinical immunology, 145(2), 719-722.e1. Elsevier 10.1016/j.jaci.2019.11.002
Gasser, Pascal; Tarchevskaya, Svetlana S; Guntern, Pascal Martin; Brigger, Daniel; Ruppli, Rahel; Zbären, Noemi; Kleinboelting, Silke; Heusser, Christoph; Jardetzky, Theodore S; Eggel, Alexander (2020). The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. Nature Communications, 11(1), p. 165. Springer Nature 10.1038/s41467-019-13815-w
Boyman, Onur; Eggel, Alexander; Noti, Mario (2018). Editorial overview: Allergy and hypersensitivity: Emerging concepts in allergy and type 2 immunity. Current opinion in immunology, 54, iii-v. Elsevier 10.1016/j.coi.2018.10.002
Gasser, Pascal; Eggel, Alexander (2018). Targeting IgE in allergic disease. Current opinion in immunology, 54, pp. 86-92. Elsevier 10.1016/j.coi.2018.05.015
Zellweger, Fabian; Buschor, Patrick; Hobi, Gabriel; Brigger, Daniel; Dahinden, Clemens A.; Villiger, Peter; Eggel, Alexander (2018). IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils. Cell death & disease, 9(5), p. 510. Nature Publishing Group 10.1038/s41419-018-0526-9
Zellweger, F.; Gasser, P.; Brigger, Daniel; Buschor, P.; Vogel, Monique; Eggel, Alexander (2017). A novel bispecific DARPin targeting FcγRIIB and FcεRI-bound IgE inhibits allergic responses. Allergy, 72(8), pp. 1174-1183. Wiley-Blackwell 10.1111/all.13109
Zellweger, Fabian; Eggel, Alexander (2016). IgE-associated allergic disorders: recent advances in etiology, diagnosis, and treatment. Allergy, 71(12), pp. 1652-1661. Wiley-Blackwell 10.1111/all.13059
Pennington, Luke F; Tarchevskaya, Svetlana; Brigger, Daniel; Sathiyamoorthy, Karthik; Graham, Michelle T; Nadeau, Kari Christine; Eggel, Alexander; Jardetzky, Theodore S (2016). Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange. Nature communications, 7(11610), p. 11610. Nature Publishing Group 10.1038/ncomms11610
Smith, Lucas K; He, Yingbo; Park, Jeong-Soo; Bieri, Gregor; Snethlage, Cedric E; Lin, Karin; Gontier, Geraldine; Wabl, Rafael; Plambeck, Kristopher E; Udeochu, Joe; Wheatley, Elizabeth G; Bouchard, Jill; Eggel, Alexander; Narasimha, Ramya; Grant, Jacqueline L; Luo, Jian; Wyss-Coray, Tony; Villeda, Saul A (2015). β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nature medicine, 21(8), pp. 932-937. Nature Publishing Group 10.1038/nm.3898
Morshed, Md. Mahbubul; Hlushchuk, Ruslan; Simon, Dagmar; Walls, Andrew F.; Obata-Ninomiya, Kazushige; Karasuyama, Hajime; Djonov, Valentin; Eggel, Alexander; Kaufmann, Thomas; Simon, Hans-Uwe; Yousefi, Shida (2014). NADPH oxidase-independent formation of extracellular DNA traps by basophils. Journal of immunology, 192(11), pp. 5314-5323. American Association of Immunologists 10.4049/jimmunol.1303418
Kim, Beomkyu; Eggel, Alexander; Tarchevskaya, Svetlana S; Vogel, Monique; Prinz, Heino; Jardetzky, Theodore S (2012). Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor. Nature, 491(7425), pp. 613-7. London: Macmillan Journals Ltd. 10.1038/nature11546
Kim, Beomkyu; Tarchevskaya, Svetlana S; Eggel, Alexander; Vogel, Monique; Jardetzky, Theodore S (2012). A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E-receptor interactions. Analytical biochemistry, 431(2), pp. 84-9. San Diego, Calif.: Elsevier 10.1016/j.ab.2012.09.010
Wurzburg, Beth A; Kim, Beomkyu; Tarchevskaya, Svetlana S; Eggel, Alexander; Vogel, Monique; Jardetzky, Theodore S (2012). An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, nonreceptor binding conformation. Journal of biological chemistry, 287(43), pp. 36251-7. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.407502
Baumann, Michael J; Eggel, Alexander; Amstutz, Patrick; Stadler, Beda M; Vogel, Monique (2010). DARPins against a functional IgE epitope. Immunology letters, 133(2), pp. 78-84. Amsterdam: Elsevier 10.1016/j.imlet.2010.07.005
Eggel, Alexander; Baumann, Michael J; Amstutz, Patrick; Stadler, Beda M; Vogel, Monique (2009). DARPins as bispecific receptor antagonists analyzed for immunoglobulin E receptor blockage. Journal of molecular biology, 393(3), pp. 598-607. Amsterdam: Elsevier 10.1016/j.jmb.2009.08.014
Bachmeier-Zbären, Noemi; Kinet, Jean-Pierre; Kaufmann, Thomas; Eggel, Alexander (2024). Mast cell activation test. In: Reference Module in Food Science (pp. 579-589). Elsevier 10.1016/B978-0-323-96018-2.00032-8
Hagmann, Björn; Odermatt, Andrea; Eggel, Alexander; Dahinden, Clemens A.; Fux, Michaela (22 August 2013). Interferon-α antagonizes IL-3-mediated immunoregulatory functions of human basophils (Unpublished). In: 15th ICI (International Congress of Immunology). Milan, Italy.
Hagmann, Björn; Odermatt, Andrea; Eggel, Alexander; Dahinden, Clemens A.; Fux, Michaela (3 April 2013). Co-activation of JAK/STAT and p38 MAPK pathways by type I interferon enhances apoptosis in human basophils (Unpublished). In: 25th Meeting of the Swiss Immunology PhD Students. Wolfsberg. 03.-05.04.2013.
