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Codilupi, Tamara; Szybinski, Jakub; Arunasalam, Stefanie; Jungius, Sarah; Dunbar, Andrew C; Stivala, Simona; Brkic, Sime; Albrecht, Camille; Vokalova, Lenka; Yang, Julie L; Buczak, Katarzyna; Ghosh, Nilabh; Passweg, Jakob R; Rovo, Alicia; Angelillo-Scherrer, Anne; Pankov, Dmitry; Dirnhofer, Stephan; Levine, Ross L; Koche, Richard and Meyer, Sara C (2024). Development of resistance to type II JAK2 inhibitors in MPN depends on AXL kinase and is targetable. Clinical cancer research, 30(3), pp. 586-599. American Association for Cancer Research 10.1158/1078-0432.CCR-23-0163
Dunbar, Andrew J; Bowman, Robert L; Park, Young C; O'Connor, Kavi; Izzo, Franco; Myers, Robert M; Karzai, Abdul; Zaroogian, Zach; Kim, Won Jun; Fernandez-Maestre, Ines; Waarts, Michael R; Nazir, Abbas; Xiao, Wenbin; Codilupi, Tamara; Brodsky, Max; Farina, Mirko; Cai, Louise; Cai, Sheng F; Wang, Benjamin; An, Wenbin; ... (2024). Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms. Cancer discovery, 14(5), pp. 737-751. American Association for Cancer Research 10.1158/2159-8290.CD-22-0952
Schoenfeld, Adam J; Lee, Sylvia M; Doger de Speville, Bernard; Gettinger, Scott N; Hafliger, Simon; Sukari, Ammar; Papa, Sophie; Rodriguez-Moreno, Juan Francisco; Graf Finckenstein, Friedrich; Fiaz, Rana; Catlett, Melissa; Chen, Guang; Qi, Rongsu; Masteller, Emma L; Gontcharova, Viktoria; He, Kai (2024). Lifileucel, an Autologous Tumor-infiltrating Lymphocyte Monotherapy, in Patients with Advanced Non-small Cell Lung Cancer Resistant to Immune Checkpoint Inhibitors. Cancer discovery, 14(8), pp. 1389-1402. American Association for Cancer Research 10.1158/2159-8290.CD-23-1334
Bianchi, Matteo; Reichen, Christian; Croset, Amelie; Fischer, Stefanie; Eggenschwiler, Aline; Grübler, Yvonne; Marpakwar, Rajlakshmi; Looser, Thamar; Spitzli, Patricia; Herzog, Christel; Villemagne, Denis; Schiegg, Dieter; Abduli, Liridon; Iss, Chloé; Neculcea, Alexandra; Franchini, Marco; Lekishvili, Tamara; Ragusa, Simone; Zitt, Christof; Kaufmann, Yvonne; ... (2024). The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells. Cancer immunology research, 12(7), pp. 921-943. American Association for Cancer Research 10.1158/2326-6066.CIR-23-0692
Poliaková Turan, Michaela; Riedo, Rahel; Medo, Matúš; Pozzato, Chiara; Friese-Hamim, Manja; Koch, Jonas Paul; Coggins, Si'Ana A; Li, Qun; Kim, Baek; Albers, Joachim; Aebersold, Daniel M; Zamboni, Nicola; Zimmer, Yitzhak; Medová, Michaela (2024). E2F1-associated purine synthesis pathway is a major component of the MET-DNA damage response network. Cancer research communications, 4(7), pp. 1863-1880. American Association for Cancer Research 10.1158/2767-9764.CRC-23-0370
Karamitopoulou, Eva; Wenning, Anna Silvia; Acharjee, Animesh; Aeschbacher, Pauline; Marinoni, Ilaria; Zlobec, Inti; Gloor, Beat; Perren, Aurel (2024). Spatial heterogeneity of immune regulators drives dynamic changes of local immune responses, affecting disease outcomes in pancreatic cancer. (In Press). Clinical cancer research American Association for Cancer Research 10.1158/1078-0432.CCR-24-0368
Vasciaveo, Alessandro; Arriaga, Juan Martin; Nunes de Almeida, Francisca; Zou, Min; Douglass, Eugene F; Picech, Florencia; Shibata, Maho; Rodriguez-Calero, Antonio; de Brot, Simone; Mitrofanova, Antonina; Chua, Chee Wai; Karan, Charles; Realubit, Ronald; Pampou, Sergey; Kim, Jaime Y; Afari, Stephanie N; Mukhammadov, Timur; Zanella, Luca; Corey, Eva; Alvarez, Mariano J; ... (2023). OncoLoop: A network-based precision cancer medicine framework. Cancer discovery, 13(2), pp. 386-409. American Association for Cancer Research 10.1158/2159-8290.CD-22-0342
Bhinder, Bhavneet; Ferguson, Alison; Sigouros, Michael; Uppal, Manik; Elsaeed, Ahmed G; Bareja, Rohan; Alnajar, Hussein; Eng, Kenneth Wha; Conteduca, Vincenza; Sboner, Andrea; Mosquera, Juan Miguel; Elemento, Olivier; Beltran, Himisha (2023). The Immunogenomic Landscape of Neuroendocrine Prostate Cancer. Clinical cancer research, 29(15), pp. 2933-2943. American Association for Cancer Research 10.1158/1078-0432.CCR-22-3743
Van Emmenis, Lucie; Ku, Sheng-Yu; Gayvert, Kaitlyn; Branch, Jonathan R; Brady, Nicholas J; Basu, Subhasree; Russell, Michael; Cyrta, Joanna; Vosoughi, Aram; Sailer, Verena; Alnajar, Hussein; Dardenne, Etienne; Koumis, Elena; Puca, Loredana; Robinson, Brian D; Feldkamp, Michael D; Winkis, Annmarie; Majewski, Nathan; Rupnow, Brent; Gottardis, Marco M; ... (2023). The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer. Cancer research communications, 3(8), pp. 1447-1459. American Association for Cancer Research 10.1158/2767-9764.CRC-22-0491
Seeber, Andreas; Battaglin, Francesca; Zimmer, Kai; Kocher, Florian; Baca, Yasmine; Xiu, Joanne; Spizzo, Gilbert; Novotny-Diermayr, Veronica; Rieder, Dietmar; Puccini, Alberto; Swensen, Jeffrey; Ellis, Michelle; Goldberg, Richard M; Grothey, Axel; Shields, Anthony F; Marshall, John L; Weinberg, Benjamin A; Sackstein, Paul E; Hon Lim, Kiat; San Tan, Gek; ... (2022). Comprehensive analysis of R-spondin fusions and RNF43 mutations implicate novel therapeutic options in colorectal cancer. Clinical cancer research, 28(9), pp. 1863-1870. American Association for Cancer Research 10.1158/1078-0432.CCR-21-3018
Widmer, Carmen A; Klebic, Ismar; Domanitskaya, Natalya; Decollogny, Morgane Francine; Howald, Denise; Siffert, Myriam; Essers, Paul; Nowicka, Zuzanna; Stokar-Regenscheit, Nadine; van de Ven, Marieke; de Korte-Grimmerink, Renske; Galván, José A; Pritchard, Colin E.J.; Huijbers, Ivo J; Fendler, Wojciech; Vens, Conchita; Rottenberg, Sven (2022). Loss of the volume-regulated anion channel components LRRC8A and LRRC8D limits platinum drug efficacy. Cancer research communications, 2(10), pp. 1266-1281. American Association for Cancer Research 10.1158/2767-9764.CRC-22-0208
Virgilio, Tommaso; Bordini, Joy; Cascione, Luciano; Sartori, Giulio; Latino, Irene; Molina Romero, Daniel; Leoni, Cristina; Akhmedov, Murodzhon; Rinaldi, Andrea; Arribas, Alberto J; Morone, Diego; Seyed Jafari, S Morteza; Bersudsky, Marina; Ottolenghi, Aner; Kwee, Ivo; Chiaravalli, Anna Maria; Sessa, Fausto; Hunger, Robert E; Bruno, Antonino; Mortara, Lorenzo; ... (2022). Subcapsular sinus macrophages promote melanoma metastasis to the sentinel lymph nodes via an IL-1α-STAT3 axis. Cancer immunology research, 10(12), pp. 1525-1541. American Association for Cancer Research 10.1158/2326-6066.CIR-22-0225
Karamitopoulou, Eva; Andreou, Andreas; Pahud de Mortanges, Aurélie; Tinguely, Marianne; Gloor, Beat; Perren, Aurel (2021). PD-1/PD-L1-Associated Immunoarchitectural Patterns Stratify Pancreatic Cancer Patients into Prognostic/Predictive Subgroups. Cancer immunology research, 9(12), pp. 1439-1450. American Association for Cancer Research 10.1158/2326-6066.CIR-21-0144
Saghafinia, Sadegh; Homicsko, Krisztian; Di Domenico, Annunziata; Wullschleger, Stephan; Perren, Aurel; Marinoni, Ilaria; Ciriello, Giovanni; Michael, Iacovos P; Hanahan, Douglas (2021). Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression. Cancer discovery, 11(10), pp. 2638-2657. American Association for Cancer Research 10.1158/2159-8290.CD-20-1637
Wirsching, Hans-Georg; Roelcke, Ulrich; Weller, Jonathan; Hundsberger, Thomas; Hottinger, Andreas F; von Moos, Roger; Caparrotti, Francesca; Conen, Katrin; Remonda, Luca; Roth, Patrick; Ochsenbein, Adrian; Tabatabai, Ghazaleh; Weller, Michael (2021). MRI and 18FET-PET Predict Survival Benefit from Bevacizumab Plus Radiotherapy in Patients with Isocitrate Dehydrogenase Wild-type Glioblastoma: Results from the Randomized ARTE Trial. Clinical cancer research, 27(1), pp. 179-188. American Association for Cancer Research 10.1158/1078-0432.CCR-20-2096
Papachristodoulou, Alexandros; Rodríguez-Calero, Antonio; Panja, Sukanya; Margolskee, Elizabeth; Virk, Renu K; Milner, Teresa A; Martina, Luis Pina; Kim, Jaime Y; Di Bernardo, Matteo; Williams, Alanna B; Maliza, Elvis A; Caputo, Joseph M; Haas, Christopher; Wang, Vinson; De Castro, Guarionex Joel; Wenske, Sven; Hibshoosh, Hanina; McKiernan, James M; Shen, Michael M; Rubin, Mark A; ... (2021). NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation. Cancer discovery, 11(9), pp. 2316-2333. American Association for Cancer Research 10.1158/2159-8290.CD-20-1765
Puccini, Alberto; Poorman, Kelsey; Salem, Mohamed E; Soldato, Davide; Seeber, Andreas; Goldberg, Richard M; Shields, Anthony F; Xiu, Joanne; Battaglin, Francesca; Berger, Martin D.; Tokunaga, Ryuma; Naseem, Madiha; Barzi, Afsaneh; Iqbal, Syma; Zhang, Wu; Soni, Shivani; Hwang, Jimmy J; Philip, Philip A; Sciallero, Stefania; Korn, W Michael; ... (2020). Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs). Clinical cancer research, 26(22), pp. 5943-5951. American Association for Cancer Research 10.1158/1078-0432.CCR-20-1804
Tosti, Nadia; Cremonesi, Eleonora; Governa, Valeria; Basso, Camilla; Kancherla, Venkatesh; Coto-Llerena, Mairene; Amicarella, Francesca; Weixler, Benjamin; Däster, Silvio; Sconocchia, Giuseppe; Majno, Pietro Edoardo; Christoforidis, Dimitri; Tornillo, Luigi; Terracciano, Luigi; Ng, Charlotte K. Y.; Piscuoglio, Salvatore; von Flüe, Markus; Spagnoli, Giulio; Eppenberger-Castori, Serenella; Iezzi, Giandomenica; ... (2020). Infiltration by IL22-Producing T Cells Promotes Neutrophil Recruitment and Predicts Favorable Clinical Outcome in Human Colorectal Cancer. Cancer immunology research, 8(11), pp. 1452-1462. American Association for Cancer Research 10.1158/2326-6066.CIR-19-0934
Seiler, Roland; Gibb, Ewan A; Wang, Natalie Q; Oo, Htoo Zarni; Lam, Hung-Ming; Van Kessel, Kim E; Winters, Brian; Erho, Nicholas G; Takhar, Mandeep M; Douglas, James; Vakar-Lopez, Funda; van Rhijn, Bas W G; Fransen van de Putte, Elisabeth E; Zwarthoff, Ellen C; Thalmann, George; Boormans, Joost L; Dall'Era, Marc; van der Heijden, Michiel S; Wright, Jonathan L and Black, Peter C (2019). Divergent biological response to neoadjuvant chemotherapy in muscle-invasive bladder cancer. Clinical cancer research, 25(16), pp. 5082-5093. American Association for Cancer Research 10.1158/1078-0432.CCR-18-1106
Haas, Quentin; Frias Boligan, Kayluz; Jandus, Camilla; Schneider, Christoph; Simillion, Cedric; Stanczak, Michal A; Haubitz, Monika; Jafari, Morteza; Zippelius, Alfred; Baerlocher, Gabriela M.; Läubli, Heinz; Hunger, Robert E.; Romero, Pedro; Simon, Hans-Uwe; von Gunten, Stephan (2019). Siglec-9 Regulates an Effector Memory CD8 T-cell Subset That Congregates in the Melanoma Tumor Microenvironment. Cancer immunology research, 7(5), pp. 707-718. American Association for Cancer Research 10.1158/2326-6066.CIR-18-0505
Pantelidou, Constantia; Sonzogni, Olmo; de Oliveira Taveira, Mateus; Mehta, Anita K; Kothari, Aditi; Wang, Dan; Visal, Tanvi; Li, Michelle K; Pinto, Jocelin; Castrillon, Jessica A; Cheney, Emily M; Bouwman, Peter; Jonkers, Jos; Rottenberg, Sven; Guerriero, Jennifer L; Wulf, Gerburg M; Shapiro, Geoffrey I (2019). PARP inhibitor efficacy depends on CD8+ T cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer. Cancer discovery, 9(6), pp. 722-737. American Association for Cancer Research 10.1158/2159-8290.CD-18-1218
Batista da Costa, José; Gibb, Ewan A; Bivalacqua, Trinity J; Liu, Yang; Oo, Htoo Zarni; Miyamoto, David T; Alshalalfa, Mohammed; Davicioni, Elai; Wright, Jonathan; Dall'Era, Marc A; Douglas, James; Boormans, Joost L; Van der Heijden, Michiel S; Wu, Chin-Lee; van Rhijn, Bas W G; Gupta, Shilpa; Grivas, Petros; Mouw, Kent W; Murugan, Paari; Fazli, Ladan; ... (2019). Molecular Characterization of Neuroendocrine-like Bladder Cancer. Clinical cancer research, 25(13), pp. 3908-3920. American Association for Cancer Research 10.1158/1078-0432.CCR-18-3558
Kim, Haesook T; Ahn, Kwang Woo; Hu, Zhen-Huan; Davids, Matthew S; Volpe, Virginia O; Antin, Joseph H; Sorror, Mohamed L; Shadman, Mazyar; Press, Oliver; Pidala, Joseph; Hogan, William; Negrin, Robert; Devine, Steven; Uberti, Joseph; Agura, Edward; Nash, Richard; Mehta, Jayesh; McGuirk, Joseph; Forman, Stephen; Langston, Amelia; ... (2019). Prognostic Score and Cytogenetic Risk Classification for Chronic Lymphocytic Leukemia Patients: Center for International Blood and Marrow Transplant Research Report. Clinical cancer research, 25(16), pp. 5143-5155. American Association for Cancer Research 10.1158/1078-0432.CCR-18-3988
Beltran, Himisha; Oromendia, Clara; Danila, Daniel C; Montgomery, Bruce; Hoimes, Christopher; Szmulewitz, Russell Z; Vaishampayan, Ulka; Armstrong, Andrew J; Stein, Mark; Pinski, Jacek; Mosquera, Juan M; Sailer, Verena; Bareja, Rohan; Romanel, Alessandro; Gumpeni, Naveen; Sboner, Andrea; Dardenne, Etienne; Puca, Loredana; Prandi, Davide; Rubin, Mark A.; ... (2019). A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers. Clinical cancer research, 25(1), pp. 43-51. American Association for Cancer Research 10.1158/1078-0432.CCR-18-1912
Kim, Richard D; Sarker, Debashis; Meyer, Tim; Yau, Thomas; Macarulla, Teresa; Park, Joong-Won; Choo, Su Pin; Hollebecque, Antoine; Sung, Max W; Lim, Ho-Yeong; Mazzaferro, Vincenzo; Trojan, Joerg; Zhu, Andrew X; Yoon, Jung-Hwan; Sharma, Sunil; Lin, Zhong-Zhe; Chan, Stephen L; Faivre, Sandrine; Feun, Lynn G; Yen, Chia-Jui; ... (2019). First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma. Cancer discovery, 9(12), pp. 1696-1707. American Association for Cancer Research 10.1158/2159-8290.CD-19-0555
Beltran, Himisha; Hruszkewycz, Andrew; Scher, Howard I; Hildesheim, Jeffrey; Isaacs, Jennifer; Yu, Evan Y; Kelly, Kathleen; Lin, Daniel; Dicker, Adam; Arnold, Julia; Hecht, Toby; Wicha, Max; Sears, Rosalie; Rowley, David; White, Richard; Gulley, James L; Lee, John; Diaz Meco, Maria; Small, Eric J; Shen, Michael; ... (2019). The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance. Clinical cancer research, 25(23), pp. 6916-6924. American Association for Cancer Research 10.1158/1078-0432.CCR-19-1423
Tokunaga, Ryuma; Xiu, Joanne; Johnston, Curtis; Goldberg, Richard M; Philip, Philip A; Seeber, Andreas; Naseem, Madiha; Lo, Jae Ho; Arai, Hiroyuki; Battaglin, Francesca; Puccini, Alberto; Berger, Martin D.; Soni, Shivani; Zhang, Wu; Hwang, Jimmy J; Shields, Anthony F; Marshall, John L; Baba, Hideo; Korn, W Michael and Lenz, Heinz-Josef (2019). Molecular Profiling of Appendiceal Adenocarcinoma and Comparison with Right-sided and Left-sided Colorectal Cancer. Clinical cancer research, 25(10), pp. 3096-3103. American Association for Cancer Research 10.1158/1078-0432.CCR-18-3388
Berger, Martin Dave; Stintzing, Sebastian; Heinemann, Volker; Cao, Shu; Yang, Dongyun; Sunakawa, Yu; Matsusaka, Satoshi; Ning, Yan; Okazaki, Satoshi; Miyamoto, Yuji; Suenaga, Mitsukuni; Schirripa, Marta; Hanna, Diana L; Soni, Shivani; Puccini, Alberto; Zhang, Wu; Cremolini, Chiara; Falcone, Alfredo; Loupakis, Fotios and Lenz, Heinz-Josef (2018). A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab. Clinical cancer research, 24(4), pp. 784-793. American Association for Cancer Research 10.1158/1078-0432.CCR-17-1663
Wartenberg, Martin; Cibin, Silvia; Zlobec, Inti; Vassella, Erik; Eppenberger-Castori, Serenella; Terracciano, Luigi; Eichmann, Micha David; Worni, Mathias; Gloor, Beat; Perren, Aurel; Karamitopoulou, Evanthia (2018). Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer Reveals Three Distinct Subtypes with Prognostic/Predictive Significance. Clinical cancer research, 24(18), pp. 4444-4454. American Association for Cancer Research 10.1158/1078-0432.CCR-17-3401
Zinn, Pascal O; Singh, Sanjay K; Kotrotsou, Aikaterini; Hassan, Islam; Thomas, Ginu; Luedi, Markus M; Elakkad, Ahmed; Elshafeey, Nabil; Idris, Tagwa; Mosley, Jennifer; Gumin, Joy; Fuller, Gregory N; deGroot, John Frederick; Baladandayuthapani, Veerabhadran; Sulman, Erik P; Kumar, Ashok J.; Sawaya, Raymond; Lang, Frederick F.; Piwnica-Worms, David and Colen, Rivka R. (2018). A co-clinical radiogenomic validation study - Conserved magnetic resonance radiomic appearance of Periostin expressing Glioblastoma in patients and xenograft models. Clinical cancer research, 24(24), pp. 6288-6299. American Association for Cancer Research 10.1158/1078-0432.CCR-17-3420
Lim, Ho Yeong; Merle, Philippe; Weiss, Karl Heinz; Yau, Thomas; Ross, Paul; Mazzaferro, Vincenzo; Blanc, Jean-Frédéric; Ma, Yuk Ting; Yen, Chia Jui; Kocsis, Judit; Choo, Su Pin; Sukeepaisarnjaroen, Wattana; Gérolami, René; Dufour, Jean-François; Gane, Edward J; Ryoo, Baek-Yeol; Peck-Radosavljevic, Markus; Dao, Thong; Yeo, Winnie; Lamlertthon, Wisut; ... (2018). Phase II Studies with Refametinib or Refametinib plus Sorafenib in Patients with -Mutated Hepatocellular Carcinoma. Clinical cancer research, 24(19), pp. 4650-4661. American Association for Cancer Research 10.1158/1078-0432.CCR-17-3588
Boysen, Gunther; Rodrigues, Daniel N; Rescigno, Pasquale; Seed, George; Dolling, David; Riisnaes, Ruth; Crespo, Mateus; Zafeiriou, Zafeiris; Sumanasuriya, Semini; Bianchini, Diletta; Hunt, Joanne; Moloney, Deirdre; Perez-Lopez, Raquel; Tunariu, Nina; Miranda, Susana; Figueiredo, Inês; Ferreira, Ana; Christova, Rossitza; Gil, Veronica; Aziz, Sara; ... (2018). SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity. Clinical cancer research, 24(22), pp. 5585-5593. American Association for Cancer Research 10.1158/1078-0432.CCR-18-0937
Triscott, Joanna; Rubin, Mark A. (2018). Prostate Power Play: Does Accelerate -Deficient Cancer Progression? Cancer discovery, 8(6), pp. 682-685. American Association for Cancer Research 10.1158/2159-8290.CD-18-0369
McKinney, Matthew; Moffitt, Andrea B; Gaulard, Philippe; Travert, Marion; De Leval, Laurence; Nicolae, Alina; Raffeld, Mark; Jaffe, Elaine S; Pittaluga, Stefania; Xi, Liqiang; Heavican, Tayla; Iqbal, Javeed; Belhadj, Karim; Delfau-Larue, Marie Helene; Fataccioli, Virginie; Czader, Magdalena B; Lossos, Izidore S; Chapman-Fredricks, Jennifer R; Richards, Kristy L; Fedoriw, Yuri; ... (2017). The Genetic Basis of Hepatosplenic T Cell Lymphoma. Cancer discovery, 7(4), pp. 369-379. American Association for Cancer Research 10.1158/2159-8290.CD-16-0330
Huang, Franklin W; Mosquera, Juan Miguel; Garofalo, Andrea; Oh, Coyin; Baco, Maria; Amin-Mansour, Ali; Rabasha, Bokang; Bahl, Samira; Mullane, Stephanie A; Robinson, Brian D; Aldubayan, Saud; Khani, Francesca; Karir, Beerinder; Kim, Eejung; Chimene-Weiss, Jeremy; Hofree, Matan; Romanel, Alessandro; Osborne, Joseph R; Kim, Jong Wook; Azabdaftari, Gissou; ... (2017). Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations. Cancer discovery, 7(9), pp. 973-983. American Association for Cancer Research 10.1158/2159-8290.CD-16-0960
Zou, Min; Toivanen, Roxanne; Mitrofanova, Antonina; Floch, Nicolas; Hayati, Sheida; Sun, Yanping; Le Magnen, Clémentine; Chester, Daniel; Mostaghel, Elahe A; Califano, Andrea; Rubin, Mark Andrew; Shen, Michael M; Abate-Shen, Cory (2017). Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-Resistant Prostate Cancer. Cancer discovery, 7(7), pp. 736-749. American Association for Cancer Research 10.1158/2159-8290.CD-16-1174
Bishop, Jennifer L; Thaper, Daksh; Vahid, Sepideh; Davies, Alastair; Ketola, Kirsi; Kuruma, Hidetoshi; Jama, Randy; Nip, Ka Mun; Angeles, Arkhjamil; Johnson, Fraser; Wyatt, Alexander W; Fazli, Ladan; Gleave, Martin E; Lin, Dong; Rubin, Mark Andrew; Collins, Colin C; Wang, Yuzhuo; Beltran, Himisha; Zoubeidi, Amina (2017). The Master Neural Transcription Factor BRN2 Is an Androgen Receptor-Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer. Cancer discovery, 7(1), pp. 54-71. American Association for Cancer Research 10.1158/2159-8290.CD-15-1263
Pauli, Chantal; Hopkins, Benjamin D; Prandi, Davide; Shaw, Reid; Fedrizzi, Tarcisio; Sboner, Andrea; Sailer, Verena; Augello, Michael; Puca, Loredana; Rosati, Rachele; McNary, Terra J; Churakova, Yelena; Cheung, Cynthia; Triscott, Joanna Catherine Caprio; Pisapia, David; Rao, Rema; Mosquera, Juan Miguel; Robinson, Brian; Faltas, Bishoy M; Emerling, Brooke E; ... (2017). Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine. Cancer discovery, 7(5), pp. 462-477. American Association for Cancer Research 10.1158/2159-8290.CD-16-1154
Pajic, Marina; Blatter, Sohvi Tuulikki; Guyader, Charlotte; Gonggrijp, Maaike; Kersbergen, Ariena; Küçükosmanoğlu, Aslι; Sol, Wendy; Drost, Rinske; Jonkers, Jos; Borst, Piet; Rottenberg, Sven (2017). Selected Alkylating Agents Can Overcome Drug Tolerance of G-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice. Clinical cancer research, 23(22), pp. 7020-7033. American Association for Cancer Research 10.1158/1078-0432.CCR-17-1279
Seipel, Katja; Marques, Miguel Teixera; Bozzini, Marie-Ange; Meinken, Christina; Mueller, Beatrice U; Pabst, Thomas (2016). Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia. Clinical cancer research, 22(3), pp. 746-756. American Association for Cancer Research 10.1158/1078-0432.CCR-15-1054
Gross, Stefanie; Lennerz, Volker; Gallerani, Elisa; Mach, Nicolas; Böhm, Steffen; Hess, Dagmar; von Boehmer, Lotta; Knuth, Alexander; Ochsenbein, Adrian; Gnad-Vogt, Ulrike; Forssmann, Ulf; Woelfel, Thomas; Kaempgen, Eckhart (2016). Short Peptide Vaccine Induces CD4+ T Helper Cells in Patients with Different Solid Cancers. Cancer immunology research, 4(1), pp. 18-25. American Association for Cancer Research 10.1158/2326-6066.CIR-15-0105
Francica, Paola; Nisa Hernandez, Lluis; Aebersold, Daniel; Langer, Rupert; Bladt, Friedhelm; Blaukat, Andree; Keogh-Stroka, Deborah M.; Martínez, María Rodríguez; Zimmer, Yitzhak; Medova, Michaela (2016). Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage-Induced Senescence Program in Gastric Cancer. Clinical cancer research, 22(21), pp. 5322-5336. American Association for Cancer Research 10.1158/1078-0432.CCR-15-2987
Feldmeyer, Laurence; Hudgens, Courtney W; Ray-Lyons, Genevieve; Nagarajan, Priyadharsini; Aung, Phyu P; Curry, Jonathan L; Torres-Cabala, Carlos A; Mino, Barbara; Rodriguez-Canales, Jaime; Reuben, Alexandre; Chen, Pei-Ling; Ko, Jennifer S; Billings, Steven D; Bassett, Roland L; Wistuba, Ignacio I; Cooper, Zachary A; Prieto, Victor G; Wargo, Jennifer A; Tetzlaff, Michael T (2016). Density, Distribution, and Composition of Immune Infiltrates Correlate with Survival in Merkel Cell Carcinoma. Clinical cancer research, 22(22), pp. 5553-5563. American Association for Cancer Research 10.1158/1078-0432.CCR-16-0392
Amstutz, Ursula; Offer, Steven M; Sistonen, Johanna; Joerger, Markus; Diasio, Robert B; Largiadèr, Carlo Rodolfo (2015). Polymorphisms in MIR27A Associated with Early-Onset Toxicity in Fluoropyrimidine-Based Chemotherapy. Clinical cancer research, 21(9), pp. 2038-2044. American Association for Cancer Research 10.1158/1078-0432.CCR-14-2817
Meyer, Sara C; Levine, Ross L (2014). Molecular pathways: molecular basis for sensitivity and resistance to JAK kinase inhibitors. Clinical cancer research, 20(8), pp. 2051-2059. American Association for Cancer Research 10.1158/1078-0432.CCR-13-0279
Wojtalla, Anna; Fischer, Barbara; Kotelevets, Nataliya; Mauri, Francesco A; Sobek, Jens; Rehrauer, Hubert; Wotzkow, Carlos; Tschan, Mario P; Seckl, Michael J; Zangemeister-Wittke, Uwe; Arcaro, Alexandre (2013). Targeting the phosphoinositide 3-kinase p110-α isoform impairs cell proliferation, survival, and tumor growth in small cell lung cancer. Clinical cancer research, 19(1), pp. 96-105. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-12-1138
Le Magnen, Clémentine; Bubendorf, Lukas; Rentsch, Cyrill A.; Mengus, Chantal; Gsponer, Joel; Zellweger, Tobias; Rieken, Malte; Thalmann, George N.; Cecchini, Marco G.; Germann, Markus; Bachmann, Alexander; Wyler, Stephen; Heberer, Michael; Spagnoli, Giulio C. (2013). Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer. Clinical cancer research, 19(19), pp. 5361-5371. American Association for Cancer Research 10.1158/1078-0432.CCR-12-2857
Guenova, Emmanuella; Watanabe, Rei; Teague, Jessica E.; Desimone, Jennifer A.; Jiang, Ying; Dowlatshahi, Mitra; Schlapbach, Christoph; Schaekel, Knut; Rook, Alain H.; Tawa, Marianne; Fisher, David C.; Kupper, Thomas S.; Clark, Rachael A. (2013). TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma. Clinical cancer research, 19(14), pp. 3755-3763. American Association for Cancer Research 10.1158/1078-0432.CCR-12-3488
Liebl, Florian; Demir, Ihsan Ekin; Rosenberg, Robert; Boldis, Alexandra; Yildiz, Esra; Kujundzic, Kristina; Kehl, Timo; Dischl, Dominic; Schuster, Tibor; Maak, Matthias; Becker, Karen; Langer, Rupert; Laschinger, Melanie; Friess, Helmut; Ceyhan, Güralp O. (2013). The severity of neural invasion is associated with shortened survival in colon cancer. Clinical cancer research, 19(1), pp. 50-61. American Association for Cancer Research 10.1158/1078-0432.CCR-12-2392
Potjer, Thomas P.; Schot, Ingrid; Langer, Peter; Heverhagen, Johannes T.; Wasser, Martin N. J. M.; Slater, Emily P.; Klöppel, Günter; Morreau, Hans M.; Bonsing, Bert A.; de Vos tot Nederveen Cappel, Wouter H.; Bargello, Mathias; Gress, Thomas M.; Vasen, Hans F. A.; Bartsch, Detlef K. (2013). Variation in precursor lesions of pancreatic cancer among high-risk groups. Clinical cancer research, 19(2), pp. 442-449. American Association for Cancer Research 10.1158/1078-0432.CCR-12-2730
Konstantinidou, Georgia; Ramadori, Giorgio; Torti, Francesca; Kangasniemi, Kim; Ramirez, Rachel E.; Cai, Yiran; Behrens, Carmen; Dellinger, Michael T.; Brekken, Rolf A.; Wistuba, Ignacio I.; Heguy, Adriana; Teruya-Feldstein, Julie; Scaglioni, Pier Paolo (2013). RHOA-FAK Is a Required Signaling Axis for the Maintenance of KRAS-Driven Lung Adenocarcinomas. Cancer discovery, 3(4), pp. 444-457. American Association for Cancer Research 10.1158/2159-8290.CD-12-0388
Patterson, Dan M; Zweifel, Martin; Middleton, Mark R; Price, Patricia M; Folkes, Lisa K; Stratford, Michael R L; Ross, Phil; Halford, Sarah; Peters, Jane; Balkissoon, Jai; Chaplin, Dai J; Padhani, Anwar R; Rustin, Gordon J S (2012). Phase I clinical and pharmacokinetic evaluation of the vascular-disrupting agent OXi4503 in patients with advanced solid tumors. Clinical cancer research, 18(5), pp. 1415-25. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-11-2414
Wulfkuhle, Julia D; Berg, Daniela; Wolff, Claudia; Langer, Rupert; Tran, Kai; Illi, Julie; Espina, Virginia; Pierobon, Mariaelena; Deng, Jianghong; DeMichele, Angela; Walch, Axel; Bronger, Holger; Becker, Ingrid; Waldhör, Christine; Höfler, Heinz; Esserman, Laura; Liotta, Lance A; Becker, Karl-Friedrich; Petricoin, Emanuel F (2012). Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping. Clinical cancer research, 18(23), pp. 6426-35. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-12-0452
Nathan, Paul; Zweifel, Martin; Padhani, Anwar R; Koh, Dow-Mu; Ng, Matthew; Collins, David J; Harris, Adrian; Carden, Craig; Smythe, Jon; Fisher, Nita; Taylor, N Jane; Stirling, J James; Lu, Shiao-Ping; Leach, Martin O; Rustin, Gordon J S; Judson, Ian (2012). Phase I trial of combretastatin A4 phosphate (CA4P) in combination with bevacizumab in patients with advanced cancer. Clinical cancer research, 18(12), pp. 3428-39. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-11-3376
Cathomas, Richard; Rothermundt, Christian; Klingbiel, Dirk; Bubendorf, Lukas; Jaggi, Rolf; Betticher, Daniel C; Brauchli, Peter; Cotting, Denise; Droege, Cornelia; Winterhalder, Ralph; Siciliano, Daniele; Berthold, Dominik R; Pless, Miklos; Schiess, Ralph; von Moos, Roger; Gillessen, Silke (2012). Efficacy of cetuximab in metastatic castration-resistant prostate cancer might depend on EGFR and PTEN expression: results from a phase II trial (SAKK 08/07). Clinical cancer research, 18(21), pp. 6049-57. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-12-2219
Llovet, Josep M; Peña, Carol E A; Lathia, Chetan D; Shan, Michael; Meinhardt, Gerold; Bruix, Jordi (2012). Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma. Clinical cancer research, 18(8), pp. 2290-300. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-11-2175
Bauer, Daniel E; Mitchell, Chelsey M; Strait, Kelly M; Lathan, Christopher S; Stelow, Edward B; Lüer, Sonja C; Muhammed, Somala; Evans, Andrew G; Sholl, Lynette M; Rosai, Juan; Giraldi, Eugenia; Oakley, Richard P; Rodriguez-Galindo, Carlos; London, Wendy B; Sallan, Stephen E; Bradner, James E; French, Christopher A (2012). Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clinical cancer research, 18(20), pp. 5773-9. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-12-1153
Patricia, Martin-Killias; Stefan, Nikolas; Rothschild, Sacha; Plückthun, Andreas; Zangemeister-Wittke, Uwe (2011). A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity. Clinical cancer research, 17(1), pp. 100-10. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-10-1303
Mortezavi, Ashkan; Hermanns, Thomas; Seifert, Hans-Helge; Baumgartner, Martin K; Provenzano, Maurizio; Sulser, Tullio; Burger, Maximilian; Montani, Matteo; Ikenberg, Kristian; Hofstädter, Ferdinand; Hartmann, Arndt; Jaggi, Rolf; Moch, Holger; Kristiansen, Glen; Wild, Peter J (2011). KPNA2 expression is an independent adverse predictor of biochemical recurrence after radical prostatectomy. Clinical cancer research, 17(5), pp. 1111-21. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-10-0081
van Kuilenburg, André B P; Largiadèr, Carlo R (2011). SNPs and Haplotypes in DPYD and Outcome of Capecitabine-Letter. Clinical cancer research, 17(17), 5837; author reply 5835-6. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-11-1258
Villablanca, Judith G; London, Wendy B; Naranjo, Arlene; McGrady, Patrick; Ames, Matthew M; Reid, Joel M; McGovern, Renee M; Buhrow, Sarah A; Jackson, Hollie; Stranzinger, Enno; Kitchen, Brenda J; Sondel, Paul M; Parisi, Marguerite T; Shulkin, Barry; Yanik, Gregory A; Cohn, Susan L; Reynolds, C Patrick (2011). Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the Children's Oncology Group. Clinical cancer research, 17(21), pp. 6858-66. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-11-0995
Dahinden, Corinne; Ingold, Barbara; Wild, Peter; Boysen, Gunther; Luu, Van-Duc; Montani, Matteo; Kristiansen, Glen; Sulser, Tullio; Bühlmann, Peter; Moch, Holger; Schraml, Peter (2010). Mining tissue microarray data to uncover combinations of biomarker expression patterns that improve intermediate staging and grading of clear cell renal cell cancer. Clinical cancer research, 16(1), pp. 88-98. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-09-0260
Mansi, Rosalba; Wang, Xuejuan; Forrer, Flavio; Kneifel, Stefan; Tamma, Maria-Luisa; Waser, Beatrice; Cescato, Renzo; Reubi, Jean-Claude; Maecke, Helmut R (2009). Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides. Clinical cancer research, 15(16), pp. 5240-9. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-08-3145
Marinov, Marin; Ziogas, Algirdas; Pardo, Olivier E; Tan, Liwen Terence; Dhillon, Tony; Mauri, Francesco A; Lane, Heidi A; Lemoine, Nicholas R; Zangemeister-Wittke, Uwe; Seckl, Michael J; Arcaro, Alexandre (2009). AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001. Clinical cancer research, 15(4), pp. 1277-87. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-08-2166
Pabst, Thomas; Mueller, Beatrice U (2009). Complexity of CEBPA dysregulation in human acute myeloid leukemia. Clinical cancer research, 15(17), pp. 5303-7. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-08-2941
Schardt, Julian A; Weber, Daniel; Eyholzer, Marianne; Mueller, Beatrice U; Pabst, Thomas (2009). Activation of the unfolded protein response is associated with favorable prognosis in acute myeloid leukemia. Clinical cancer research, 15(11), pp. 3834-41. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-08-2870
Körner, Meike; Waser, Beatrice; Reubi, Jean-Claude (2008). High expression of neuropeptide Y1 receptors in ewing sarcoma tumors. Clinical cancer research, 14(16), pp. 5043-9. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-07-4551
Ginj, Mihaela; Zhang, Hanwen; Eisenwiener, Klaus-Peter; Wild, Damian; Schulz, Stefan; Rink, Hans; Cescato, Renzo; Reubi, Jean Claude; Maecke, Helmut R (2008). New pansomatostatin ligands and their chelated versions: affinity profile, agonist activity, internalization, and tumor targeting. Clinical cancer research, 14(7), pp. 2019-27. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-07-1687
Amstutz, Ursula; Farese, Simone; Aebi, Stefan; Largiadèr, Carlo R (2008). Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapy. Clinical cancer research, 27(1), p. 54. Philadelphia, Pa.: American Association for Cancer Research 10.1186/1756-9966-27-54
Gautschi, Oliver; Heighway, Jim; Mack, Philip C; Purnell, Phillip R; Lara, Primo N; Gandara, David R (2008). Aurora kinases as anticancer drug targets. Clinical cancer research, 14(6), pp. 1639-48. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-07-2179
Fleischmann, Achim; Schlomm, Thorsten; Huland, Hartwig; Köllermann, Jens; Simon, Philipp; Mirlacher, Martina; Salomon, Georg; Chun, Felix H K; Steuber, Thomas; Simon, Ronald; Sauter, Guido; Graefen, Markus; Erbersdobler, Andreas (2008). Distinct subcellular expression patterns of neutral endopeptidase (CD10) in prostate cancer predict diverging clinical courses in surgically treated patients. Clinical cancer research, 14(23), pp. 7838-42. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-08-1432
Huang, J.; Grotzer, M. A.; Watanabe, T.; Hewer, Ekkehard; Pietsch, T.; Rutkowski, S.; Ohgaki, H. (2008). Mutations in the Nijmegen Breakage Syndrome Gene in Medulloblastomas. Clinical cancer research, 14(13), pp. 4053-4058. American Association for Cancer Research 10.1158/1078-0432.CCR-08-0098
Wicki, Andreas; Wild, Damian; Storch, Daniel; Seemayer, Christian; Gotthardt, Martin; Behe, Martin; Kneifel, Stefan; Mihatsch, Michael J; Reubi, Jean-Claude; Mäcke, Helmut R; Christofori, Gerhard (2007). [Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptor-targeted therapy for insulinoma. Clinical cancer research, 13(12), pp. 3696-705. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-06-2965
von Holzen, Urs; Pataer, Abujiang; Raju, Uma; Bocangel, Dora; Vorburger, Stephan A; Liu, Yanna; Lu, Xiaolin; Roth, Jack A; Aggarwal, Bharat B; Barber, Glen N; Keyomarsi, Khandan; Hunt, Kelly K; Swisher, Stephen G (2007). The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation. Clinical cancer research, 13(20), pp. 6032-9. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-06-2932
Kneifel, Stefan; Cordier, Dominik; Good, Stephan; Ionescu, Mihai C S; Ghaffari, Anthony; Hofer, Silvia; Kretzschmar, Martin; Tolnay, Markus; Apostolidis, Christos; Waser, Beatrice; Arnold, Marlene; Mueller-Brand, Jan; Maecke, Helmut R; Reubi, Jean Claude; Merlo, Adrian (2006). Local targeting of malignant gliomas by the diffusible peptidic vector 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid-substance p. Clinical cancer research, 12(12), pp. 3843-50. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-05-2820
