Heterogeneous Genetic Location of mcr-1 in Colistin-Resistant Escherichia coli Isolated from Humans and Retail Chicken Meat in Switzerland: Emergence of mcr-1-Carrying IncK2 Plasmids.

Donà, Valentina; Bernasconi, Odette Joëlle; Do Couto Pires, Joao Pedro; Collaud, Alexandra; Overesch, Gudrun; Ramette, Alban Nicolas; Perreten, Vincent; Endimiani, Andrea (2017). Heterogeneous Genetic Location of mcr-1 in Colistin-Resistant Escherichia coli Isolated from Humans and Retail Chicken Meat in Switzerland: Emergence of mcr-1-Carrying IncK2 Plasmids. Antimicrobial agents and chemotherapy, 61(11) American Society for Microbiology 10.1128/AAC.01245-17

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We characterized the genetic environment of mcr-1 in colistin-resistant Escherichia coli strains isolated in Switzerland during 2014-2016 from humans (n=3) and chicken meat (n=6). Whole genome and plasmid sequencing identified mcr-1 integrated in IncX4 (of which, one carrying the mcr-1.2 variant), IncI2, IncHI2 and novel IncK2 plasmids (overall, n=7), as well as in the bacterial chromosome (n=2) in single or duplicate copies. Our study supports the easy mobilization of mcr-1 across diverse genetic locations.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology > Molecular Bacterial Epidemiology and Infectiology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > General Bacteriology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Donà, Valentina; Bernasconi, Odette Joëlle; Do Couto Pires, Joao Pedro; Collaud, Alexandra; Overesch, Gudrun; Ramette, Alban Nicolas; Perreten, Vincent and Endimiani, Andrea

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Funders:

[4] Swiss National Science Foundation

Projects:

[577] SNF project 153377 to Andrea Endimiani

Language:

English

Submitter:

Andrea Endimiani

Date Deposited:

27 Nov 2017 15:26

Last Modified:

27 Nov 2017 15:34

Publisher DOI:

10.1128/AAC.01245-17

PubMed ID:

28848010

BORIS DOI:

10.7892/boris.105699

URI:

https://boris.unibe.ch/id/eprint/105699

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