Tumor Heterogeneity in Primary Colorectal Cancer and Corresponding Metastases. Does the Apple Fall Far From the Tree?

Blank, Annika; Roberts, Daniel Edward; Dawson, Heather; Zlobec, Inti; Lugli, Alessandro (2018). Tumor Heterogeneity in Primary Colorectal Cancer and Corresponding Metastases. Does the Apple Fall Far From the Tree? Frontiers in medicine, 5, p. 234. Frontiers 10.3389/fmed.2018.00234

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Colorectal cancer harbors tremendous heterogeneity, with temporal and spatial differences in genetic mutations, epigenetic regulation, and tumor microenvironment. Analyzing the distribution and frequency of genetic, epigenetic, and microenvironment differences within a given tumor and between different sites of a metastatic tumor has been used as a powerful tool to investigate tumorigenesis, tumor progression, and to yield insight into various models of tumor development. A better understanding of tumor heterogeneity would have tremendous clinical relevance, which may manifest most clearly when genetic analyses to inform treatment decisions are performed on a very limited sample of a large tumor. This review summarizes the current concepts of tumor heterogeneity, with a focus on primary colorectal cancers and their corresponding metastases as well as potential clinical implications.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Translational Research Unit
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology

UniBE Contributor:

Blank, Annika; Dawson, Heather; Zlobec, Inti and Lugli, Alessandro

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2296-858X

Publisher:

Frontiers

Language:

English

Submitter:

Alessandro Lugli

Date Deposited:

28 Nov 2018 15:05

Last Modified:

02 Dec 2018 02:41

Publisher DOI:

10.3389/fmed.2018.00234

PubMed ID:

30234115

Uncontrolled Keywords:

cancer stem cells clonal evolution colorectal cancer heterogeneity metastases

BORIS DOI:

10.7892/boris.121736

URI:

https://boris.unibe.ch/id/eprint/121736

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