Clément, Mathieu; Keller, Peter Michael; Bernasconi, Odette Joëlle; Stirnimann, Guido; Frey, Pascal M.; Bloemberg, Guido V.; Sendi, Parham; Endimiani, Andrea (2019). First Clinical Case of In Vivo Acquisition of DHA-1 plasmid-mediated AmpC in a Salmonella enterica subsp. enterica Isolate. Antimicrobial agents and chemotherapy, 63(10) American Society for Microbiology 10.1128/AAC.00992-19
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A pan-susceptible Salmonella enterica serovar Worthington was detected in the stools of a man returning from Sri Lanka. Under ceftriaxone treatment, a third-generation cephalosporin (3GCs)-resistant Salmonella Worthington was isolated after 8 days. Molecular analyses indicated that the two isolates were identical. However, the latter strain acquired a blaDHA-1-carrying IncFII plasmid probably from a Citrobacter amalonaticus colonizing the gut. This is the first report of in vivo acquisition of plasmid-mediated resistance to 3GCs in Salmonella enterica.
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