First Clinical Case of In Vivo Acquisition of DHA-1 plasmid-mediated AmpC in a Salmonella enterica subsp. enterica Isolate

Clément, Mathieu; Keller, Peter Michael; Bernasconi, Odette Joëlle; Stirnimann, Guido; Frey, Pascal Marcel; Bloemberg, Guido V.; Sendi, Parham; Endimiani, Andrea (2019). First Clinical Case of In Vivo Acquisition of DHA-1 plasmid-mediated AmpC in a Salmonella enterica subsp. enterica Isolate. Antimicrobial agents and chemotherapy, 63(10) American Society for Microbiology 10.1128/AAC.00992-19

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A pan-susceptible Salmonella enterica serovar Worthington was detected in the stools of a man returning from Sri Lanka. Under ceftriaxone treatment, a third-generation cephalosporin (3GCs)-resistant Salmonella Worthington was isolated after 8 days. Molecular analyses indicated that the two isolates were identical. However, the latter strain acquired a blaDHA-1-carrying IncFII plasmid probably from a Citrobacter amalonaticus colonizing the gut. This is the first report of in vivo acquisition of plasmid-mediated resistance to 3GCs in Salmonella enterica.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > General Bacteriology
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Clément, Mathieu; Keller, Peter Michael; Bernasconi, Odette Joëlle; Stirnimann, Guido; Frey, Pascal Marcel; Sendi, Parham and Endimiani, Andrea

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Funders:

[4] Swiss National Science Foundation

Projects:

[1124] Whole Genome and Plasmid Sequencing for MDR Enterobacteriaceae Simultaneously Isolated from Multiple Human and Non-Human Settings: Deciphering Impact, Risks, and Dynamics for Resistance Transmission and Spread

Language:

English

Submitter:

Andrea Endimiani

Date Deposited:

26 Aug 2019 15:45

Last Modified:

24 Oct 2019 02:30

Publisher DOI:

10.1128/AAC.00992-19

PubMed ID:

31358582

BORIS DOI:

10.7892/boris.132247

URI:

https://boris.unibe.ch/id/eprint/132247

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