Cannabinoid Receptor Type-2 in B Cells Is Associated with Tumor Immunity in Melanoma.

Gruber, Thomas; Robatel, Steve; Kremenovic, Mirela; Bäriswyl, Lukas; Gertsch, Jürg; Schenk, Mirjam (2021). Cannabinoid Receptor Type-2 in B Cells Is Associated with Tumor Immunity in Melanoma. Cancers, 13(8) MDPI AG 10.3390/cancers13081934

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Agents targeting the endocannabinoid system (ECS) have gained attention as potential cancer treatments. Given recent evidence that cannabinoid receptor 2 (CB2R) regulates lymphocyte development and inflammation, we performed studies on CB2R in the immune response against melanoma. Analysis of The Cancer Genome Atlas (TCGA) data revealed a strong positive correlation between CB2R expression and survival, as well as B cell infiltration in human melanoma. In a murine melanoma model, CB2R expression reduced the growth of melanoma as well as the B cell frequencies in the tumor microenvironment (TME), compared to CB2R-deficient mice. In depth analysis of tumor-infiltrating B cells using single-cell RNA sequencing suggested a less differentiated phenotype in tumors from Cb2r-/- mice. Thus, in this study, we demonstrate for the first time a protective, B cell-mediated role of CB2R in melanoma. This gained insight might assist in the development of novel, CB2R-targeted cancer therapies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine
04 Faculty of Medicine > Service Sector > Institute of Pathology > Tumour Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Gruber, Thomas; Robatel, Steve Jacquy; Kremenovic, Mirela; Bäriswyl, Lukas; Gertsch, Jürg and Schenk, Mirjam

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2072-6694

Publisher:

MDPI AG

Language:

English

Submitter:

Andrea Stettler

Date Deposited:

25 Jun 2021 16:53

Last Modified:

25 Jun 2021 16:53

Publisher DOI:

10.3390/cancers13081934

PubMed ID:

33923757

Uncontrolled Keywords:

CB2R cannabinoid receptor type-2 endocannabinoid system melanoma regulatory B cells

BORIS DOI:

10.48350/157152

URI:

https://boris.unibe.ch/id/eprint/157152

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