In vitro-ex vivo model systems for nanosafety assessment

Wick, P.; Chortarea, S.; Guenat, Olivier Thierry; Roesslein, M.; Stucki, Janick; Hirn, S.; Petri-Fink, A.; Rothen-Rutishauser, B. (2015). In vitro-ex vivo model systems for nanosafety assessment. European Journal of Nanomedicine, 7(3), pp. 169-179. De Gruyter 10.1515/ejnm-2014-0049

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Engineered nanomaterials have unique and novel properties enabling wide-ranging new applications in nearly all fields of research. As these new properties have raised concerns about potential adverse effects for the environment and human health, extensive efforts are underway to define reliable, cost- and time-effective, as well as mechanistic-based testing strategies to replace the current method of animal testing, which is still the most prevalent model used for the risk assessment of chemicals. Current approaches for nanomaterials follow this line. The aim of this review is to explore and qualify the relevance of new in vitro and ex vivo models in (nano)material safety assessment, a crucial prerequisite for translation into applications.

Item Type:

Journal Article (Review Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Lung Regeneration Technologies
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Guenat, Olivier Thierry and Stucki, Janick

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1662-5986

Publisher:

De Gruyter

Language:

English

Submitter:

Olivier Thierry Guenat

Date Deposited:

10 Jun 2015 14:01

Last Modified:

01 Jul 2016 02:30

Publisher DOI:

10.1515/ejnm-2014-0049

BORIS DOI:

10.7892/boris.69084

URI:

https://boris.unibe.ch/id/eprint/69084

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