Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences.

Tietz, Silvia; Zwahlen, Marcel; Haghayegh Jahromi, Neda; Baden, Pascale; Lazarevic, Ivana; Enzmann, Gaby; Engelhardt, Britta (2016). Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences. European journal of immunology, 46(10), pp. 2481-2483. Wiley-VCH 10.1002/eji.201546272

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Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis. Surprisingly, refined EAE scoring failed to improve statistical outcome comparing the overall disease courses between two groups of mice.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Tietz, Silvia; Zwahlen, Marcel; Haghayegh Jahromi, Neda; Baden, Pascale; Lazarevic, Ivana; Enzmann, Gaby and Engelhardt, Britta

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0014-2980

Publisher:

Wiley-VCH

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

16 Feb 2017 15:35

Last Modified:

27 Jun 2017 12:01

Publisher DOI:

10.1002/eji.201546272

PubMed ID:

27469626

Uncontrolled Keywords:

Area under the curve; Bland-Altman plots; Clinical scoring; Experimental autoimmune encephalomyelitis; Statistical analysis

BORIS DOI:

10.7892/boris.95355

URI:

https://boris.unibe.ch/id/eprint/95355

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