Bosshart, Patrick; Kalbermatter, David; Bonetti, Sara; Fotiadis, Dimitrios (2019). Structure and function of a monocarboxylate transporter homolog specific for L-lactate. Molecular & cellular oncology, 6(6), e1646605. Taylor & Francis 10.1080/23723556.2019.1646605
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Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structure-function analysis provides insights into the molecular working mechanisms of ligand binding and L-lactate transport.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Faculty Institutions > NCCR TransCure 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Bosshart, Patrick, Kalbermatter, David, Bonetti, Sara, Fotiadis, Dimitrios José |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
2372-3556 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Barbara Franziska Järmann-Bangerter |
Date Deposited: |
23 Dec 2019 15:02 |
Last Modified: |
05 Dec 2022 15:34 |
Publisher DOI: |
10.1080/23723556.2019.1646605 |
PubMed ID: |
31692891 |
Uncontrolled Keywords: |
L-lactate transporter SLC16 family monocarboxylate transporter structure transport mechanism |
BORIS DOI: |
10.7892/boris.136805 |
URI: |
https://boris.unibe.ch/id/eprint/136805 |
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