SARS-CoV-2 Inhibition by Sulfonated Compounds.

Gasbarri, Matteo; V'kovski, Philip; Torriani, Giulia; Thiel, Volker; Stellacci, Francesco; Tapparel, Caroline; Cagno, Valeria (2020). SARS-CoV-2 Inhibition by Sulfonated Compounds. Microorganisms, 8(12) MDPI 10.3390/microorganisms8121894

Preview

Text b152077.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (474kB) | Preview

Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) depends on angiotensin converting enzyme 2 (ACE2) for cellular entry, but it might also rely on attachment receptors such as heparan sulfates. Several groups have recently demonstrated an affinity of the SARS-CoV2 spike protein for heparan sulfates and a reduced binding to cells in the presence of heparin or heparinase treatment. Here, we investigated the inhibitory activity of several sulfated and sulfonated molecules, which prevent interaction with heparan sulfates, against vesicular stomatitis virus (VSV)-pseudotyped-SARS-CoV-2 and the authentic SARS-CoV-2. Sulfonated cyclodextrins and nanoparticles that have recently shown broad-spectrum non-toxic virucidal activity against many heparan sulfates binding viruses showed inhibitory activity in the micromolar and nanomolar ranges, respectively. In stark contrast with the mechanisms that these compounds present for these other viruses, the inhibition against SARS-CoV-2 was found to be simply reversible.

Interest & Impact

Downloads

116 since deposited on 11 Mar 2021
89 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item