Blacksell, Stuart D; Dhawan, Sandhya; Kusumoto, Marina; Le, Kim Khanh; Summermatter, Kathrin; O'Keefe, Joseph; Kozlovac, Joseph; Almuhairi, Salama Suhail; Sendow, Indrawati; Scheel, Christina M; Ahumibe, Anthony; Masuku, Zibusiso M; Bennett, Allan M; Kojima, Kazunobu; Harper, David R; Hamilton, Keith (2023). The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory-Foot and Mouth Disease Virus. Applied Biosafety, 28(4), pp. 199-215. Sage 10.1089/apb.2022.0041
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INTRODUCTION
Foot and mouth disease (FMD) is a highly contagious infection of cloven-hoofed animals. The Biosafety Research Road Map reviewed scientific literature regarding the foot and mouth disease virus (FMDV). This project aims to identify gaps in the data required to conduct evidence-based biorisk assessments, as described by Blacksell et al., and strengthen control measures appropriate for local and national laboratories.
METHODS
A literature search was conducted to identify potential gaps in biosafety and focused on five main sections: the route of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination strategies.
RESULTS
The available data regarding biosafety knowledge gaps and existing evidence have been collated. Some gaps include the need for more scientific data that identify the specific safety contribution of engineering controls, support requirements for showering out after in vitro laboratory work, and whether a 3- to 5-day quarantine period should be applied to individuals conducting in vitro versus in vivo work. Addressing these gaps will contribute to the remediation and improvement of biosafety and biosecurity systems when working with FMDV.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology |
UniBE Contributor: |
Summermatter, Kathrin |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
2470-1246 |
Publisher: |
Sage |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
14 Dec 2023 14:03 |
Last Modified: |
15 Dec 2023 05:20 |
Publisher DOI: |
10.1089/apb.2022.0041 |
PubMed ID: |
38090355 |
Uncontrolled Keywords: |
biorisk management biosafety evidence biosafety knowledge gap analysis foot and mouth disease pathogen characteristics |
BORIS DOI: |
10.48350/190330 |
URI: |
https://boris.unibe.ch/id/eprint/190330 |
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