Schwitter, Janine; Branca, Mattia; Bicvic, Antonela; Abbühl, Lena S.; Suter-Riniker, Franziska; Leib, Stephen L.; Dietmann, Anelia (2024). Long-term sequelae after viral meningitis and meningoencephalitis are frequent, even in mildly affected patients, a prospective observational study. Frontiers in neurology, 15 Frontiers Media S.A. 10.3389/fneur.2024.1411860
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Introduction: An increasing number of studies demonstrate that viral meningitis and meningoencephalitis, even those with a mild course of meningitis, can result in residual sequelae.
Methods: We aimed to investigate the long-term outcome in both viral meningitis and meningoencephalitis/encephalitis patients and impact of long-term sequelae on patients’ social and professional daily lives in a prospective observational study with a follow-up period of 20 months.
Results: A total of 50 patients (12% encephalitis, 58% meningoencephalitis and 30% meningitis) and 21 control persons participated in the study. The most common cause was the tick-borne encephalitis (TBE) virus. The most important persistent signs and symptoms after 2 years were subjective cognitive impairment (36%), fatigue and/or excessive daytime sleepiness (31%), disturbed nighttime sleep (31%) and headaches (13%), as well as feeling more rapidly exhausted after cognitive effort (53%). Independent of disease severity in the acute phase, almost one third of patients still reported mildly impaired social and/or professional life due to the long-term sequelae, with scores in the health status assessment still significantly lower compared to healthy controls.
Discussion: Regardless of the severity of the acute illness and despite constant improvement within 2 years, 67% of patients still had persistent signs and symptoms, but these were only relevant to everyday social or professional life in about 30% of these patients.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology 04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR) |
UniBE Contributor: |
Branca, Mattia, Bicvic, Antonela, Abbühl, Lena Simone, Suter, Franziska Marta, Leib, Stephen, Dietmann, Anelia |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
1664-2295 |
Publisher: |
Frontiers Media S.A. |
Language: |
English |
Submitter: |
Stephen Leib |
Date Deposited: |
23 Jul 2024 07:47 |
Last Modified: |
23 Jul 2024 07:56 |
Publisher DOI: |
10.3389/fneur.2024.1411860 |
BORIS DOI: |
10.48350/199137 |
URI: |
https://boris.unibe.ch/id/eprint/199137 |
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