Hoffmann, Anneliese; Jakob, Martin; Ochsenreiter, Torsten (2016). A novel component of the mitochondrial genome segregation machinery in trypanosomes. Microbial cell, 3(8), pp. 352-354. Shared Science Publishers OG 10.15698/mic2016.08.519
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We recently described a new component (TAC102) of the mitochondrial genome segregation machinery (mtGSM) in the protozoan parasite Trypanosoma brucei. T. brucei belongs to a group of organisms that contain a single mitochondrial organelle with a single mitochondrial genome (mt-genome) per cell. The mt- genome consists of 5000 minicircles (1 kb) and 25 maxicircles (23 kb) that are catenated into a large network. After replication of the network its segrega- tion is driven by the separating basal bodies, which are homologous structures to the centrioles organiz- ing the spindle apparatus in many eukaryotes. The structure connecting the basal body to the mt- genome was named the Tripartite Attachment Com- plex (TAC) owing its name to the distribution across three areas in the cell including the two mitochondri- al membranes.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Hoffmann, Anneliese, Jakob, Martin, Ochsenreiter, Torsten |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
2311-2638 |
Publisher: |
Shared Science Publishers OG |
Funders: |
[4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Torsten Ochsenreiter |
Date Deposited: |
22 Aug 2016 11:19 |
Last Modified: |
17 Jul 2023 06:18 |
Publisher DOI: |
10.15698/mic2016.08.519 |
PubMed ID: |
28357371 |
BORIS DOI: |
10.7892/boris.86201 |
URI: |
https://boris.unibe.ch/id/eprint/86201 |
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